A new allele, HLA-B*4212, identified in a Brazilian volunteer bone marrow donors by sequence-based typing
| Autor: | Fernanda Ribas, Rafael Gustavo Vargas, Maria da Graça Bicalho, Fabiana Poerner, S. B. Mattar, Pryscilla Fanini Wowk, Clineu Julien Seki Uehara |
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| Rok vydání: | 2010 |
| Předmět: |
Molecular Sequence Data
Immunology Human leukocyte antigen Biology Exon Bone Marrow Valine Genetics medicine Humans Point Mutation Amino Acid Sequence Allele Molecular Biology Alleles Genetics (clinical) Sequence (medicine) Base Sequence Histocompatibility Testing Sequence Analysis DNA General Medicine Molecular biology Tissue Donors HLA-B medicine.anatomical_structure Amino Acid Substitution HLA-B Antigens Glycine Bone marrow Brazil |
| Zdroj: | International Journal of Immunogenetics. 37:517-518 |
| ISSN: | 1744-3121 |
| DOI: | 10.1111/j.1744-313x.2010.00950.x |
| Popis: | Summary Here we report the discovery of a novel HLA-B allele, named B*4212 in a Brazilian volunteer bone marrow donor. The new sequence has nucleotide variation at position 496 (TG) as compared with B*4201. This variation results in a conservative amino acid substitution from valine to glycine at codon 165 of exon 3. |
| Databáze: | OpenAIRE |
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