Involvement of neuroleptic drugs in selenium deficiency and sudden death of cardiac origin: Study and human post-mortem examination
| Autor: | Fanny Vaillant, Zahida Mamou, Bernard Bui-Xuan, Quadiri Timour, Guy Chazot, Leila Dehina, A. Tabib, Muriel Bost, Jacques Descotes, Lamia Hamdan |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty chemistry.chemical_element Physiology Autopsy Left ventricular hypertrophy medicine.disease_cause Biochemistry Sudden death Inorganic Chemistry Death Sudden Selenium Selenium deficiency Internal medicine medicine Humans chemistry.chemical_classification business.industry Glutathione peroxidase food and beverages Dilated cardiomyopathy Middle Aged medicine.disease Endocrinology chemistry Molecular Medicine Female business Oxidative stress Antipsychotic Agents |
| Zdroj: | Journal of Trace Elements in Medicine and Biology. 26:170-173 |
| ISSN: | 0946-672X |
| Popis: | The involvement of psychotropic drugs in sudden deaths has been highlighted. The objective of this work was to establish a link between selenium levels in heart tissue, psychotropic treatment and sudden death. Selenium levels were measured by electrothermal atomic absorption spectroscopy post-mortem in heart, brain and liver. Histological examination evidenced dilated cardiomyopathy in 45% of cases, left ventricular hypertrophy in 36%, and ischemic coronaropathy in 18%. A significant reduction of myocardial selenium levels compared to controls was seen in patients treated with neuroleptic drugs or meprobamate. No changes in brain or liver selenium levels were seen. These results suggest that selenium deficiency can facilitate sudden death in patients on psychotropic drugs. The reduced activity of glutathione peroxidase due to selenium deficiency can result in augmented oxidative stress in myocardial cells and myocardiopathy leading to sudden death. |
| Databáze: | OpenAIRE |
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