The effectiveness of Janus kinase inhibitors in treating atopic dermatitis: A systematic review and meta-analysis
| Autor: | Bukola Mary Ibitoye, Fakhre Alam Khattak, Stephen Shumack, Mohammad Tahir Yousafzai, Charan Jeet Arora |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Future studies Eczema Dermatology Eczema Area and Severity Index law.invention Dermatitis Atopic 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Medicine Humans Janus Kinase Inhibitors Database search engine Protein Kinase Inhibitors Janus kinase inhibitor business.industry Pruritus General Medicine Atopic dermatitis medicine.disease 030220 oncology & carcinogenesis Meta-analysis business Janus kinase |
| Zdroj: | Dermatologic therapyREFERENCES. 33(4) |
| ISSN: | 1529-8019 |
| Popis: | Primary studies have presented conflicting results on the efficacy of Janus kinase (JAK) inhibitors in treating atopic dermatitis. Hence, it is important to determine the summary effect of JAK inhibitors in order to guide the clinical application of this potentially beneficial drug. To determine the efficacy of JAK inhibitors in treating atopic dermatitis in all age groups. A systematic review with meta-analyses of randomized controlled trials (RCTs) reporting on the effect of JAK inhibitors on the signs and symptoms of atopic dermatitis were conducted. Six electronic databases, registries, and search engines (PubMed, Cochrane Central Register of Controlled Trials [CENTRAL], Google Scholar, ScienceDirect, Clinical.gov, and WHO ICTRP) were searched from inception to September, 2019. The search terms include "atopic dermatitis," "eczema," and "Janus kinase inhibitor." The search was restricted to humans. A total of 413 studies were identified through the database search and hand-searching. After the selection process, five RCTs were included in this systematic review. A meta-analysis of three studies showed that JAK inhibitors were effective in reducing Eczema Area and Severity Index (P = .0001) and pruritus scores (P = .0001). JAK inhibitors appear to be effective in treating atopic dermatitis. Future studies should aim to evaluate its cost-effectiveness and availability to patients especially in developing countries. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |