The Incidence of Cancer Among Acromegaly Patients: Results From the German Acromegaly Registry
| Autor: | Christina Dimopoulou, Christof Schöfl, Günter K. Stalla, Manuel Mai, Martin Grussendorf, Anke Tönjes, David Petroff, C. Jaursch-Hancke, Michael Droste, Jochen Schopohl |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Population Context (language use) Biochemistry Endocrinology Internal medicine Germany Neoplasms Acromegaly Medicine Humans Registries Insulin-Like Growth Factor I education Aged education.field_of_study business.industry Human Growth Hormone Incidence (epidemiology) Incidence Biochemistry (medical) Cancer Middle Aged medicine.disease Confidence interval Systemic inflammatory response syndrome Female business Rare disease |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 100(10) |
| ISSN: | 1945-7197 |
| Popis: | Acromegaly is a rare disease characterized by high serum levels of GH and IGF-1. Animal studies have demonstrated links between these hormones and cancer, but data regarding cancer incidence among acromegaly patients are inconsistent. Moreover, therapy options have changed considerably since many of the aforementioned data were collected.The objective was to determine whether the overall and site-specific incidence of cancer is comparable to that of the general population.Data from the German Acromegaly Registry for 446 patients (6656 person-years from diagnosis) treated in seven specialized endocrine centers were analyzed.Standard incidence ratios (SIRs) were calculated as compared to the general population.Overall cancer incidence was slightly but not significantly lower than in the general population (SIR, 0.75; 95% confidence interval, 0.55 to 1.00; P = .051) and was not significantly higher for colorectal, breast, thyroid, prostate, and lung cancers. The SIRs of those with GH in the ranges1, 1-2.5, and ≥ 2.5 ng/mL were 0.75, 0.44, and 0.92, respectively (P = .94). There was not a significant dependence on normal vs elevated IGF-1 (P = .87), radiation therapy (P = .45), disease duration (P = .96), age at diagnosis (P = .15), or during a period of high GH and IGF-1 from 8 years before to 2 years after diagnosis of acromegaly (P = .41).Cancer screening strategies need to take incidence into account, which does not seem to be substantially higher in treated acromegaly patients than in the general population for any site of cancer. |
| Databáze: | OpenAIRE |
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