Moderate offspring exercise offsets the harmful effects of maternal protein deprivation on mitochondrial function and oxidative balance by modulating sirtuins

Autor: José Carlos da Silva Junior, Anderson Apolonio Pedroza, Diorginis Soares Ferreira, Dayane Aparecida Gomes, Cristiane de Moura Freitas, Talitta Ricarlly Lopes de Arruda Lima, Claudia Jacques Lagranha, Elenilson Maximino Bernardo, Severina Cassia de Andrade Silva, Allifer Rosendo Pereira
Rok vydání: 2021
Předmět:
Male
medicine.medical_specialty
Time Factors
Low protein
Heart Diseases
Bioenergetics
Offspring
Endocrinology
Diabetes and Metabolism
Nutritional Status
Medicine (miscellaneous)
030209 endocrinology & metabolism
Oxidative phosphorylation
030204 cardiovascular system & hematology
medicine.disease_cause
Antioxidants
Mitochondria
Heart
Running
03 medical and health sciences
0302 clinical medicine
Pregnancy
Physical Conditioning
Animal
Internal medicine
Lactation
Diet
Protein-Restricted
medicine
Animals
Sirtuins
Rats
Wistar
Treadmill
Nutrition and Dietetics
biology
Sirtuin 1
business.industry
Malnutrition
Age Factors
Maternal Nutritional Physiological Phenomena
Oxidative Stress
Endocrinology
medicine.anatomical_structure
Prenatal Exposure Delayed Effects
biology.protein
Female
Energy Metabolism
Reactive Oxygen Species
Cardiology and Cardiovascular Medicine
business
Oxidative stress
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases. 31:1622-1634
ISSN: 0939-4753
DOI: 10.1016/j.numecd.2021.01.006
Popis: Background and aims It has been demonstrated that maternal low protein during development induces mitochondrial dysfunction and oxidative stress in the heart. Moderate-intensity exercise in early life, conversely, increases the overall cardiac health. Thus, we hypothesize that moderate-intensity exercise performed during young age could ameliorate the deleterious effect of maternal protein deprivation on cardiac bioenergetics. Methods and results We used a rat model of maternal protein restriction during gestational and lactation period followed by an offspring treadmill moderate physical training. Pregnant rats were divided into two groups: normal nutrition receiving 17% of casein in the diet and undernutrition receiving a low-protein diet (8% casein). At 30 days of age, the male offspring were further subdivided into sedentary (NS and LS) or exercised (NT and LT) groups. Treadmill exercise was performed as follows: 4 weeks, 5 days/week, 60 min/day at 50% of maximal running capacity. Our results showed that a low-protein diet decreases oxidative metabolism and mitochondrial function associated with higher oxidative stress. In contrast, exercise rescues mitochondrial capacity and promotes a cellular resilience to oxidative stress. Up-regulation of cardiac sirtuin 1 and 3 decreased acetylation levels, redeeming from the deleterious effect of protein restriction. Conclusion Our findings show that moderate daily exercise during a young age acts as a therapeutical intervention opposing the harmful effects of a maternal diet restricted in protein.
Databáze: OpenAIRE
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