Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets
| Autor: | Michèle Schwald, Mbaye Cisse, Félicien Karege |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Blood Platelets
Male Senescence Aging medicine.medical_specialty Central nervous system Hippocampus Neurotrophic factors Internal medicine medicine Animals RNA Messenger Rats Wistar Brain-derived neurotrophic factor Developmental profile biology Brain-Derived Neurotrophic Factor General Neuroscience Human brain Frontal Lobe Rats medicine.anatomical_structure Endocrinology Animals Newborn nervous system biology.protein Psychology Neurotrophin |
| Zdroj: | Neuroscience Letters. 328:261-264 |
| ISSN: | 0304-3940 |
| Popis: | The brain-derived neurotrophic factor (BDNF) has been involved in pre- and postnatal brain development. Moreover, abundant levels of this neurotrophin have been found in animal and human brain and serum. This study was aimed to assess the postnatal change profile of both serum and brain BDNF levels. By using immunoassay and reverse transcription-polymerase chain reaction methods, BDNF protein and mRNA levels were determined in serum and platelets, respectively, and in two brain structures (hippocampus and frontal cortex) of postnatal rats (one and three weeks old), young adults (two months old) and in aged animals (two years old). The results showed that brain and serum BDNF levels underwent similar changes during maturation and aging processes (analysis of variance (ANOVA): P |
| Databáze: | OpenAIRE |
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