Biological determinants of serum ICAM-1, E-selectin, P-selectin and L-selectin levels in healthy subjects: the Stanislas study
| Autor: | Daniel Lambert, Anne Ponthieux, Suzanne Droesch, Sophie Visvikis, Nadia Haddy, Bernard Herbeth |
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| Přispěvatelé: | Génétique épidémiologique et moléculaire des pathologies cardiovasculaires, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2003 |
| Předmět: |
Blood Glucose
Male P-selectin MESH: Apolipoprotein A-I 030204 cardiovascular system & hematology MESH: Regression Analysis Body Mass Index Leukocyte Count 0302 clinical medicine MESH: Alkaline Phosphatase MESH: Child Medicine MESH: L-Selectin Homeostasis L-Selectin Child 2. Zero hunger 0303 health sciences ICAM-1 MESH: Middle Aged biology Smoking Age Factors MESH: Enzyme-Linked Immunosorbent Assay Middle Aged Intercellular Adhesion Molecule-1 3. Good health P-Selectin C-Reactive Protein MESH: Homeostasis Child Preschool MESH: P-Selectin Alkaline phosphatase Regression Analysis L-selectin Female Cardiology and Cardiovascular Medicine MESH: Contraceptives Oral E-Selectin Adult medicine.medical_specialty MESH: E-Selectin MESH: Smoking Adolescent Aspartate transaminase Enzyme-Linked Immunosorbent Assay MESH: Erythrocyte Count MESH: Body Mass Index 03 medical and health sciences MESH: Aspartate Aminotransferases Sex Factors MESH: Sex Factors Internal medicine E-selectin MESH: C-Reactive Protein Humans MESH: Platelet Count Aspartate Aminotransferases 030304 developmental biology MESH: Adolescent MESH: Age Factors MESH: Humans Apolipoprotein A-I business.industry Platelet Count Tumor Necrosis Factor-alpha MESH: Intercellular Adhesion Molecule-1 C-reactive protein MESH: Child Preschool MESH: Adult Alkaline Phosphatase MESH: Male Endocrinology MESH: Leukocyte Count MESH: Tumor Necrosis Factor-alpha Immunology biology.protein MESH: Blood Glucose Erythrocyte Count [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business Body mass index MESH: Female Contraceptives Oral |
| Zdroj: | Atherosclerosis Atherosclerosis, Elsevier, 2004, 172 (2), pp.299-308. ⟨10.1016/j.atherosclerosis.2003.11.003⟩ Atherosclerosis, 2004, 172 (2), pp.299-308. ⟨10.1016/j.atherosclerosis.2003.11.003⟩ |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2003.11.003⟩ |
| Popis: | Background: Circulating levels of adhesion molecules increase in various inflammation-related diseases, such as atherosclerosis. However, data about factors influencing their concentrations in physiological conditions are scarce. Methods: We have studied the determinants of serum levels of intercellular adhesion molecule-1 (ICAM-1), E-selectin, P-selectin and L-selectin in a sample of healthy individuals: 303 children (4–17 years) and 493 adults (18–55 years). The concentrations of these molecules have been measured by enzyme-linked immunosorbant assay. Results: As far as the children are concerned, a decrease in the levels of ICAM-1, E-selectin, P-selectin and L-selectin has been noticed for both boys and girls aged 4–17 years, without any difference between genders. For the adults, no age-related variation has been found for the ICAM-1, E-selectin and P-selectin levels, while the L-selectin level decreased until 55 years old. In the adult group, no sex-related difference in the concentrations of ICAM-1, E-selectin and L-selectin has been seen. As to the P-selectin level, men had significantly higher levels than women. Multiple regression analysis showed that smoking, homeostasis model assessment (HOMA) index, aspartate aminotransferase (AST), alkaline phosphatase (ALP) and C-reactive protein (CRP) were significant positive determinants of the ICAM-1 concentration, whereas age and apo AI were negative ones. The E-selectin level was positively associated with body mass index (BMI), leukocyte, platelet and erythrocyte counts, glucose, ALP and tumor necrosis factor-alpha (TNF-α), and negatively related to the use of oral contraceptive (OC). Positive determinants of the P-selectin concentration were leukocyte, platelet and erythrocyte counts, whereas sex, the use of oral contraceptive, glucose and TNF-α were negative determinants of P-selectin. Only two determinants have been noticed for the concentration of serum L-selectin: age, which was negatively correlated, and leukocyte count, which was positively associated. Conclusion: Our study contributes to the understanding of the regulation of adhesion molecules in physiological conditions. |
| Databáze: | OpenAIRE |
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