Beneficial effects of bradykinin on porcine ischemic myocardium
| Autor: | W. H. Van Gilst, C. D. J. de Langen, Tom J.M. Tobé, KJ Bel, RA Tio, Harry Wesseling |
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| Přispěvatelé: | Cardiovascular Centre (CVC) |
| Rok vydání: | 1991 |
| Předmět: |
Male
OCCLUSION Physiology Swine medicine.medical_treatment Infarction Blood Pressure Coronary Disease Balloon chemistry.chemical_compound Norepinephrine Heart Rate VENTRICULAR-TACHYCARDIA Renin REPERFUSION Cardiac Output PROGRAMMED ELECTRICAL STIMULATION Saline Creatine Kinase ISCHEMIA medicine.anatomical_structure Cardiology CAPTOPRIL Cardiology and Cardiovascular Medicine INFARCTION Artery medicine.drug medicine.medical_specialty Epinephrine CORONARY-ARTERY Ischemia Bradykinin Myocardial Reperfusion LIMIT Physiology (medical) Internal medicine medicine INJURY Animals PIG business.industry Myocardium Balloon catheter Captopril medicine.disease Electric Stimulation chemistry RAT business |
| Zdroj: | Basic Research in Cardiology, 86(2), 107-116. SPRINGER HEIDELBERG |
| ISSN: | 0300-8428 |
| Popis: | Exogenous bradykinin was administered to pigs in which an experimental infarction was evoked by ischemia and reperfusion. Ischemia (45 min) was induced in a closed-chest model with a balloon catheter in the left anterior descending artery, reperfusion by deflating and removing the balloon. The pigs were treated with saline (n = 11) or bradykinin (0.1 mg/kg in 30 min) infusion (n = 10) during the last 15 min of the ischemic period and the first 15 min of reperfusion.During ischemia, heart rate increased in the saline group to 120 +/- 9% of the initial value (p Two weeks after the infarction, six pigs had died in each group. In three out of five surviving saline-treated pigs and one out of four surviving bradykinin-treated pigs, a sustained ventricular tachyarrhythmia was inducible after programmed electrical stimulation.In conclusion, although systemically administered bradykinin caused a temporary increase in myocardial ischemia, it did reduce the (enzymatic indices of) infarct size. Therefore, the beneficial effects, previously found for ACE-inhibitors might at least partially be related to the potentiation of endogenous bradykinin. |
| Databáze: | OpenAIRE |
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