Invasive Pneumococcal Disease in Persons With Predisposing Factors is Dominated by Non-vaccine Serotypes in Southwest Sweden
| Autor: | Rune Andersson, Gunilla Ockborn, Birger Trollfors, Åsa Mellgren, Erik Backhaus, Tor Härnqvist, Mats S. Dahl, Helena Kolberg, Johanna Karlsson, Susann Skovbjerg, Karin Bergman |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Serotype medicine.medical_specialty 030106 microbiology PCV13 Infectious and parasitic diseases RC109-216 Serogroup Pneumococcal conjugate vaccine Pneumococcal Vaccines 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Pneumococcal serotype 030212 general & internal medicine Child Retrospective Studies Sweden business.industry Pneumococcal conjugated vaccine Infant Retrospective cohort study Invasive pneumococcal disease medicine.disease Vaccination Causality Pneumonia Pneumococcal infections Infectious Diseases Quellung reaction business Meningitis medicine.drug Research Article |
| Zdroj: | BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-11 (2021) BMC Infectious Diseases |
| Popis: | Background The pneumococcal conjugate vaccine PCV7 was introduced in Southwest Sweden in the child vaccination program in 2009, followed by PCV13 in 2010 and PCV10 in 2015. In this retrospective cohort study we assessed the pneumococcal serotype distribution in relation to predisposing factors, clinical manifestations and outcome during seven years after PCV introduction. Methods Clinical data from 1278 patients with 1304 episodes of invasive pneumococcal disease (IPD) between January 2009 and December 2015 in Region Västra Götaland, Sweden, were retrospectively collected from medical records. Pneumococcal isolates were serotyped by gel diffusion and/or Quellung reactions performed at the Public Health Agency in Sweden. Associations between serotypes and clinical characteristics were statistically evaluated by use of Fisher’s exact test, Mann-Whitney U test and Logistic regression analysis, whereas IPD episodes caused by serotypes over time were analyzed by Mantel-Haenszel chi-square test. Results With the exception of serotype 3, the prevalence of PCV13 serotypes decreased during the study period, from 76% (n = 157) of all IPD episodes in 2009 to 25% (n = 42) in 2015 (p p Conclusions Non-PCV13 serotypes caused the majority of IPD cases in Southwest Sweden, especially in patients ≥65 years and in patients with predisposing factors. Serotype 3, included in PCV13, was prevalent and often caused severe disease. |
| Databáze: | OpenAIRE |
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