Radiotherapy Issues After Neoadjuvant Chemotherapy
Autor: | Jay R. Harris, Kimberley S. Mak |
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Rok vydání: | 2015 |
Předmět: |
Oncology
Cancer Research medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Mastectomy Segmental law.invention Breast cancer Randomized controlled trial law Internal medicine parasitic diseases medicine Breast-conserving surgery Humans Postoperative Period Stage (cooking) business.industry Chemoradiotherapy Adjuvant General Medicine medicine.disease Neoadjuvant Therapy Radiation therapy Axilla medicine.anatomical_structure Chemotherapy Adjuvant Practice Guidelines as Topic Female Radiotherapy Adjuvant business Mastectomy Chemoradiotherapy |
Zdroj: | JNCI Monographs. 2015:87-89 |
ISSN: | 1745-6614 1052-6773 |
Popis: | Radiotherapy (RT) is standard following neoadjuvant chemotherapy (NCT) and breast-conserving surgery. NCT leads to pathologic down-staging, allowing some patients to undergo breast-conserving therapy (BCT) instead of mastectomy. BCT can also be considered in select stage III patients who respond well to NCT. Clearly-negative surgical margins should be obtained in all patients undergoing BCT. RT is used selectively following NCT and mastectomy. Indications for RT have not been fully established; retrospective data and results from National Surgical Adjuvant Breast and Bowel Project B-18 and B-27 currently form the basis for recommending RT. Patients with locally advanced breast cancer should receive postmastectomy RT (PMRT). Patients with residual nodal involvement require PMRT. Stage I-II patients with a pathologic complete response do not require PMRT. Patients without residual nodal involvement, but with residual breast involvement represent an intermediate-risk group. NCT also provides down-staging in the axilla. The role of axillary RT in the setting of NCT is under investigation in ongoing randomized trials. |
Databáze: | OpenAIRE |
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