4-day triple therapy with rabeprazole, amoxicillin and clarithromycin in the eradication of Helicobacter pylori in patients with peptic ulcer disease - - A pilot study
| Autor: | Manfred V. Singer, C. B. Kölbel, S Lüth, S Teyssen |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Peptic Ulcer medicine.medical_specialty medicine.drug_class Peptic Urea breath test Rabeprazole Proton-pump inhibitor Pilot Projects Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Drug Administration Schedule Helicobacter Infections Pharmacotherapy Clarithromycin Internal medicine medicine Humans Aged Helicobacter pylori medicine.diagnostic_test biology business.industry Amoxicillin Middle Aged Anti-Ulcer Agents biology.organism_classification digestive system diseases Benzimidazoles Drug Therapy Combination Female business Omeprazole medicine.drug |
| Zdroj: | Zeitschrift für Gastroenterologie. 39:279-285 |
| ISSN: | 1439-7803 0044-2771 |
| DOI: | 10.1055/s-2001-12873 |
| Popis: | Background: It is well established that a 7-day triple therapy achieves eradication rates of Helicobacter pylori between 90% and 95%. Due to a lack of highly effective short-term eradication studies the aim of the present pilot study was to investigate the effect of a 4-day triple therapy with the new proton pump inhibitor rabeprazole (20 mg b. i. d.) in combination with clarithromycin (500 mg b. i. d.) and amoxicillin (1 g b. i. d.) without acid-suppressive pre-treatment in patients with H. pylori-related peptic ulcer disease. Methods: 20 patients (11 men, 9 women) with endoscopically diagnosed peptic ulcers (gastric ulcer: n = 5; duodenal ulcer: n = 9; combined gastric and duodenal ulcer: n = 2, gastric or duodenal ulcer scars: n = 4) and H. pylori infection were consecutively recruited. The Helicobacter pylori status was assessed by means of histology, CLO (urea-) test and C 13 -urea breath test (C 13 -UBT) at entry. Treatment success was determined by C 13 -UBT 35-42 days after end of treatment. Results: In 18 out of the 20 patients (90%) [77-100%, 95%-CI] a negative test result was found in C 13 -UBT 35-42 days after treatment. The 2 patients who remained H. pylori-positive had a duodenal ulcer. Conclusion: A 4-day triple therapy of rabeprazole in combination with clarithromycin and amoxicillin seems to be highly effective in eradicating H. pylori and well tolerated in patients with gastric and duodenal ulcer disease. The achieved eradication rate of 90% is comparable with the established 7-day triple therapy regimens. On the basis of these results and considering costs, side effects and compliance a large number of patients should be enrolled in a confirmatory 4-day eradication trial. |
| Databáze: | OpenAIRE |
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