Surgical Outcomes in Resected Non-small Cell Lung Cancer ≤ 1 cm in Diameter
| Autor: | Yu Chung Wu, Jung-Sen Liu, Bing Yen Wang, Chih-Cheng Hsieh, Wen Hu Hsu, Min Hsiung Huang, Biing Shiun Huang, Jung Jyh Hung, Wen Juei Jeng |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms Multivariate analysis predictor survival subcentimeter Carcinoma Non-Small-Cell Lung medicine Humans General hospital Lung cancer non-small cell lung cancer sublobar resection Aged Medicine(all) lcsh:R5-920 business.industry Hazard ratio General Medicine Middle Aged medicine.disease Sublobar resection Chin Confidence interval Surgery Survival Rate Treatment Outcome medicine.anatomical_structure Lymph Node Excision Female Non small cell Neoplasm Recurrence Local lcsh:Medicine (General) business |
| Zdroj: | Journal of the Chinese Medical Association, Vol 73, Iss 6, Pp 308-313 (2010) |
| ISSN: | 1726-4901 |
| DOI: | 10.1016/s1726-4901(10)70066-6 |
| Popis: | Background: The goal of this study was to investigate the prognostic factors and patterns of recurrence in patients with resected non-small cell lung cancer (NSCLC) ≤ 1 cm in diameter. Methods: We conducted a retrospective review of the clinicopathological characteristics of 71 patients with NSCLC ≤ 1 cm in diameter in Taipei Veterans General Hospital between 1982 and 2007. Overall survival and its predictors were analyzed. Results: Median follow-up time of the 71 patients was 33.3 months. Complete resection was performed in 68 patients (95.8%) with stage I disease. The 5- and 10-year overall survival rates of patients who underwent complete resections were 81.7% and 44.9%, respectively. There was tumor recurrence in 6 (8.8%) of these 68 patients. Five (9.3%) of 54 patients who underwent standard resection experienced tumor recurrence, but only 1 (7.1%) of 14 patients who received sublobar resection had recurrent disease. The difference was not statistically significant (p = 0.569). Multivariate analysis revealed that sublobar resection (hazard ratio, 5.00; 95% confidence interval, 1.28–20.00; p = 0.020) was a significant predictor for worse overall survival. Conclusion: Survival in patients with NSCLC ≤ 1 cm in diameter is satisfactory. Sublobar resection, performed in patients unfit for standard resection, is a poor prognostic factor for overall survival. [J Chin Med Assoc 2010;73(6):308–313] |
| Databáze: | OpenAIRE |
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