Anti-inflammatory actions of endogenous and exogenous interleukin-10 versus glucocorticoids on macrophage functions of the newly born

Autor: Hardik Patel, Olena Predtechenska, Kavita Kasat, Dennis Davidson, Ivana Vancurova
Rok vydání: 2014
Předmět:
Zdroj: Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
0743-8346
DOI: 10.1038/jp.2014.16
Popis: OBJECTIVE To determine whether specific macrophage immune functions of the newly born are insensitive to the actions of therapeutic levels of dexamethasone (DEX), previously measured in infants with bronchopulmonary dysplasia (BPD), compared to betamethasone (BETA) and exogenous or endogenous interleukin-10 (IL-10). STUDY DESIGN Macrophages were differentiated from cord blood monocytes (N=18). A serial dose response (around 10−8M), in vitro study was used to examine the effect of DEX, BETA and IL-10, on pro-inflammatory (PI) cytokine release, phagocytosis and respiratory burst. RESULTS Exogenous IL-10 (10−8M) significantly (p
Databáze: OpenAIRE
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