Anti-inflammatory actions of endogenous and exogenous interleukin-10 versus glucocorticoids on macrophage functions of the newly born
Autor: | Hardik Patel, Olena Predtechenska, Kavita Kasat, Dennis Davidson, Ivana Vancurova |
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Rok vydání: | 2014 |
Předmět: |
medicine.medical_specialty
Phagocytosis dexamethasone Endogeny betamethasone Article Internal medicine bronchopulmonary dysplasia Humans Medicine Macrophage Interleukin 8 respiratory burst Interleukin 6 Glucocorticoids biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Macrophages Interleukin-8 Infant Newborn phagocytosis Obstetrics and Gynecology cytokines Interleukin-10 3. Good health Respiratory burst Interleukin 10 Endocrinology inflammation Pediatrics Perinatology and Child Health Immunology biology.protein Tumor necrosis factor alpha business |
Zdroj: | Journal of perinatology : official journal of the California Perinatal Association |
ISSN: | 1476-5543 0743-8346 |
DOI: | 10.1038/jp.2014.16 |
Popis: | OBJECTIVE To determine whether specific macrophage immune functions of the newly born are insensitive to the actions of therapeutic levels of dexamethasone (DEX), previously measured in infants with bronchopulmonary dysplasia (BPD), compared to betamethasone (BETA) and exogenous or endogenous interleukin-10 (IL-10). STUDY DESIGN Macrophages were differentiated from cord blood monocytes (N=18). A serial dose response (around 10−8M), in vitro study was used to examine the effect of DEX, BETA and IL-10, on pro-inflammatory (PI) cytokine release, phagocytosis and respiratory burst. RESULTS Exogenous IL-10 (10−8M) significantly (p |
Databáze: | OpenAIRE |
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