Interaction of Arsenous Acid with the Dithiol-Type Chelator British Anti-Lewisite (BAL): Structure and Stability of Species Formed in an Unexpectedly Complex System
| Autor: | Tamás Kiss, Attila Jancsó, Zoltán Kele, Levente I. Szekeres, Béla Gyurcsik |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Metal ions in aqueous solution Dimercaprol Dithiol 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Inorganic Chemistry 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry medicine Arsenous acid Chelation Metalloid British anti-lewisite Physical and Theoretical Chemistry medicine.drug |
| Zdroj: | Inorganic chemistry. 57(12) |
| ISSN: | 1520-510X |
| Popis: | British anti-Lewisite (2,3-dimerkaptopropan-1-ol, dimercaprol, BAL) is one of the best-known chelator-type therapeutic agents against toxic metal ions and metalloids, especially arsenicals. Surprisingly, the mechanisms of action at the molecular level, as well as the coordination features of this traditional drug toward various arsenicals, are still poorly revealed. The present study on the interaction of arsenous acid (H |
| Databáze: | OpenAIRE |
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