Comorbidity of Stevens–Johnson syndrome and neutropenia associated with lamotrigine: a case report
| Autor: | Koji Tsuruga, Kazuhiko Nakamura, Norio Yasui-Furukori, Kojiro Hashimoto |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Neutropenia Bipolar disorder Comorbidity Lamotrigine Young Adult White blood cell Medicine Humans Medical history Voltage-Gated Sodium Channel Blockers Leukopenia business.industry Triazines Stevens–Johnson syndrome medicine.disease Rash Dermatology Psychiatry and Mental health medicine.anatomical_structure Anesthesia Stevens-Johnson Syndrome Female medicine.symptom business medicine.drug |
| Zdroj: | General Hospital Psychiatry. 36(6):761.e9-761.e11 |
| ISSN: | 0163-8343 |
| DOI: | 10.1016/j.genhosppsych.2014.07.010 |
| Popis: | A 19-year-old woman with a medical history of depressive mood arrived and was treated with lamotrigine at 25 mg/day. On day 10, a high fever of 39.3°C and a diffuse, erythematous, pruritic full-body rash involving the palms of her hands and the soles of her feet developed, and she was diagnosed with Stevens-Johnson syndrome (SJS). On day 17, white blood cell count (WBC) result was 1,240/μl with 54.1% neutrophils (670/μl), and the WBC decreased to 840/μl with 60.7% neutrophils (510/μl) on day 18. The trend toward improvement included skin symptoms after steroid pulse therapy using 1000 mg/day. Based on the clinical course, we concluded that the SJS and leukopenia and/or neutropenia are associated with lamotrigine. Monitoring of WBC should be kept in mind when administering lamotrigine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect