Immunogenicity of a live bivalent non-enterotoxigenic Escherichia coli (non-ETEC) vaccine and dietary clinoptilolite efficacy against postweaning diarrheal disease of pigs due to F4+ and F18+ ETEC strains
| Autor: | Vince, Silvijo, Večkovec, Ana Marija, Valpotić, Hrvoje, Špoljarić, Daniel, Žura Žaja, Ivona, Đuričić, Dražen, Leiner, Denis, Šavorić, Juraj, Butković, Ivan, Habrun, Boris, Njari, Bela, Kovšca Janjatović, Ana, Efendić, Maša, Samardžija, Marko, Popović, Maja, Valpotić, Ivica, Špoljarić, Branimira |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Veterinarski arhiv. 92:259-276 |
| ISSN: | 1331-8055 0372-5480 |
| Popis: | No safe and effective vaccine exists against porcine enterotoxigenic Escherichia coli (ETEC) strains, which are the etiological agents of post-weaning diarrhoea (PWD), economically one of the most significant diseases of swine, which encountered for major productive losses in swine industry worldwide. The current study was designed to evaluate: (1) efficacy of an oral bivalent F4ac+/F18ac+ non-ETEC live vaccine candidate (VACCINE) in stimulating systemic and intestinal cellular immunity in 4-week-old weaned pigs, (2) the onset and duration of protective immunity of weaned pigs against naturally occurring PWD during the period of 6 weeks following weaning, and (3) the dietary supplement potential of zeolite clinoptilolite (CPL), an antimicrobial mineral and/or immunomodulator/ vaccine adjuvant (VACCINE + CPL). The pigs immunized either with the VACCINE or its combination with dietary CPL had significantly increased body weight gain from Day 7 to Day 42 (P |
| Databáze: | OpenAIRE |
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