Outcome of anal and rectal melanoma: has site of origin a prognostic value? Analysis of 287 patients
| Autor: | Francesco Carlei, Andrea Ciarrocchi, Gianfranco Amicucci, R. Pietroletti |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Rectal Melanoma medicine.medical_specialty education.field_of_study business.industry medicine.medical_treatment Melanoma Hazard ratio Population Rectum Anal canal medicine.disease Confidence interval Radiation therapy medicine.anatomical_structure Internal medicine medicine Surgery business education |
| Popis: | To investigate the prognostic role of site of origin for primary anorectal melanoma. Data regarding patients affected by primary melanoma of the anal canal and rectum were retrieved from the surveillance, epidemiology, and end results database. Age, gender, tumor stage, tumor location, receipt of radiotherapy, and type of surgical intervention were introduced as covariates in a Cox proportional hazards regression model. Our population constituted of 177 patients affected by anal canal melanoma and 110 by rectal melanoma. Tumor stage resulted to be the only independent predictor of survival (P = 0.002; hazards ratio 1.819; 95 % confidence interval 1.255–2.636). Tumor location failed to reach statistical significance. Site of origin of anorectal melanoma does not affect overall survival in patients undergoing surgery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|