Common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder
| Autor: | Shufei Zhang, Junjing Wang, Guanmao Chen, Chen Niu, Ping Chen, Huiqing Hu, Lixiang Chen, Ruiwang Huang, Sunkai Lai, Li Huang, Feng Deng, Ying Wang, Shuming Zhong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Bipolar Disorder SFG superior frontal gyrus ORBsup orbital part superior frontal gyrus CSF cerebrospinal fluid Affective disorder lcsh:RC346-429 Functional connectivity ORBmid orbital part middle frontal gyrus 0302 clinical medicine Limbic system Limbic System Gray Matter ACC anterior cingulate cortex Regular Article Organ Size dmPFC dorsomedial prefrontal cortex Middle Aged Magnetic Resonance Imaging medicine.anatomical_structure HIP hippocampus Neurology GMV gray matter volume DLPFC dorsolateral prefrontal cortex Major depressive disorder lcsh:R858-859.7 Female RSFC resting-state functional connectivity Adult medicine.medical_specialty Adolescent Cognitive Neuroscience Prefrontal Cortex lcsh:Computer applications to medicine. Medical informatics behavioral disciplines and activities R-fMRI Resting-state fMRI VBM voxel-based morphometry OFC orbitofrontal cortex Young Adult 03 medical and health sciences Neuroimaging YMRS Young Mania Rating Scale Internal medicine mental disorders medicine Humans Radiology Nuclear Medicine and imaging In patient Bipolar disorder WM white matter lcsh:Neurology. Diseases of the nervous system Depressive Disorder Major business.industry THA thalamus Voxel-based morphometry medicine.disease 030227 psychiatry VLPFC ventrolateral prefrontal cortex Endocrinology Multimodal GM gray matter Orbitofrontal cortex Neurology (clinical) business HDRS Hamilton Depression Rating Scale 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 20, Iss, Pp 42-50 (2018) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| Popis: | Major depressive disorder (MDD) and bipolar disorder (BD) are common severe affective diseases. Although previous neuroimaging studies have investigated brain abnormalities in MDD or BD, the structural and functional differences between these two disorders remain unclear. In this study, we adopted a multimodal approach, combining voxel-based morphometry (VBM) and functional connectivity (FC), to study the common and distinct structural and functional alterations in unmedicated MDD and BD patients. The VBM analysis revealed that both the MDD and BD patients showed decreased gray matter volume (GMV) in the left anterior cingulate cortex (ACC_L) and right hippocampus (HIP_R) compared with the healthy controls, and the MDD patients showed decreased GMV in the left superior frontal gyrus (SFG_L) and ACC_L compared with the BD patients. Furthermore, we took these clusters as seed regions to analyze the abnormal resting-state functional connectivity (RSFC) in the patients. We found that both the MDD and BD groups had decreased RSFC between the ACC_L and the left orbitofrontal cortex (OFC_L) and that the MDD group had decreased RSFC between the SFG_L and the HIP_L, compared with the healthy controls. Our results revealed that the MDD and BD patients were more similar than different in GMV and RSFC. These findings indicate that investigating the frontal-limbic system could be useful for understanding the underlying mechanisms of these two disorders. Highlights • Both MDD and BD patients had reduced GMV in the ACC_L and HIP_R compared with HC. • MDD patients had decreased GMV in the ACC_L and SFG_L compared with BD patients. • Both BD and MDD patients had decreased ACC-OFC RSFC compared with HC. • The MDD and BD patients were more similar than different in GMV and RSFC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|