Effects of cardioselective and nonselective beta-adrenergic blockade on the performance of highly trained runners
| Autor: | Albert A. Hartzell, Jack H. Wilmore, Beau J. Freund, Michael J. Joyner, Gordon A. Ewy, Richard L. Anderson, Carl A. Todd |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
medicine.medical_specialty Propranolol Running Oxygen Consumption Heart Rate Internal medicine Heart rate medicine Humans Treadmill Respiratory exchange ratio Pulmonary Gas Exchange business.industry Respiration VO2 max Atenolol Blockade Anesthesia Exercise Test Cardiology Breathing Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The American Journal of Cardiology. 55:D149-D154 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(85)91072-0 |
| Popis: | Twenty-five highly trained runners with a maximal oxygen uptake (V0 2 Max) of 64.7 ± 4.3 mi · kg −1 · min −1 were administered clinically equivalent doses of a nonselective (propranolol) and a cardioselective (atenolol) β-blocking agent as well as a placebo. The subjects performed a horizontal treadmill test on the eighth day and a 10-km track race on the tenth day of each treatment. Beta blockade decreased submaximal heart rate and propranolol caused the largest decrease. Beta blockade caused a decrease in maximal heart rate, V0 2 Max, maximal ventilation, maximal respiratory exchange ratio and treadmill time. Propranolol caused a greater decrease than atenolol in each of these values. The 10-km race times were significantly slower during β blockade, and propranolol race times were significantly slower than atenolol race times. It is concluded that the performance of highly trained distance runners is significantly altered by β-adrenergic blockade and that nonselective agents reduce performance to a greater extent than cardioselective agents. |
| Databáze: | OpenAIRE |
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