Role of Short Chain Fatty Acid Receptors in Intestinal Physiology and Pathophysiology
| Autor: | Kumar Kotlo, Pradeep K. Dudeja, Brian T. Layden, Medha Priyadarshini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
biology Short-chain fatty acid Nutrient sensing Gut flora biology.organism_classification Fatty Acids Volatile Energy homeostasis Article Cell biology Receptors G-Protein-Coupled 03 medical and health sciences Intestinal Diseases 030104 developmental biology Immune system Gene Expression Regulation Animals Humans Secretion Receptor Hormone |
| Zdroj: | Comprehensive Physiology |
| Popis: | Nutrient sensing is a mechanism for organisms to sense their environment. In larger animals, including humans, the intestinal tract is a major site of nutrient sensing for the body, not surprisingly, as this is the central location where nutrients are absorbed. In the gut, bacterial fermentation results in generation of short chain fatty acids (SCFAs), a class of nutrients, which are sensed by specific membrane bound receptors, FFA2, FFA3, GPR109a, and Olfr78. These receptors are expressed uniquely throughout the gut and signal through distinct mechanisms. To date, the emerging data suggests a role of these receptors in normal and pathological conditions. The overall function of these receptors is to regulate aspects of intestinal motility, hormone secretion, maintenance of the epithelial barrier, and immune cell function. Besides in intestinal health, a prominent role of these receptors has emerged in modulation of inflammatory and immune responses during pathological conditions. Moreover, these receptors are being revealed to interact with the gut microbiota. This review article updates the current body of knowledge on SCFA sensing receptors in the gut and their roles in intestinal health and disease as well as in whole body energy homeostasis. © 2017 American Physiological Society. Compr Physiol 8:1091-1115, 2018. |
| Databáze: | OpenAIRE |
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