Can topical application of tranexamic acid reduce blood loss in thoracic surgery? A prospective randomised double blind investigation
| Autor: | Andrea Dell’Amore, Giulia Luciano, Alessandro Bini, Giampiero Dolci, Asadi Nizar, Domenico Greco, Guido Caroli, Franco Stella, Nicola Cassanelli |
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| Přispěvatelé: | Andrea Dell’Amore, Guido Caroli, Asadi Nizar, Nicola Cassanelli, Giulia Luciano, Domenico Greco, Giampiero Dolci, Alessandro Bini, Franco Stella |
| Rok vydání: | 2012 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Blood transfusion medicine.medical_treatment Administration Topical BLOOD LOSS Blood Loss Surgical Postoperative Hemorrhage Placebo Double-Blind Method Blood product Surgical Antifibrinolytic agent medicine Humans Blood Transfusion Prospective Studies Antifibrinolityc agents Blood saving Postoperative bleeding Thoracic surgery Tranexamic acid Aged Antifibrinolytic Agents Female Middle Aged Tranexamic Acid Thoracic Surgery tranexamic acid Saline business.industry Cardiac surgery Surgery Topical Cardiothoracic surgery Anesthesia Administration Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Heart, lungcirculation. 21(11) |
| ISSN: | 1444-2892 |
| Popis: | Objective The systemic or topical use of antifibrinolytic agents is effective in reducing postoperative bleeding and blood product transfusion in cardiac surgery. We sought to study the effect of the topical application of tranexamic acid into the pleural space to reduce postoperative bleeding after lung surgery. Methods This was a prospective randomised double blind placebo controlled investigation. From May-2010 to February-2012, 89-patients, scheduled for pulmonary resection, were randomly allocated to one of the two study groups. Group-A received 5 g of tranexamic-acid in 100 ml of saline solution. Group-B received 100 ml of saline solution as placebo. Results The blood loss in the first 12-h was significantly less in group-A. The same trend was observed in the first 24-h but without reaching a true statistical significance. The mean volume of blood transfusion was statistically lower in group-A. The analysis between post-operative haemoglobin concentration, haematocrit, platelet-count, international-normalised-ratio, fibrinogen and partial-thromboplastin-time of both groups was not statistically significant. Conclusion In our experience, the topical use of tranexamic-acid after lung surgery reduces postoperative bleeding and blood transfusion volume. The topical administration of tranexamic-acid is safe without increasing the risk of post-operative complications related to pharmacological side-effects. |
| Databáze: | OpenAIRE |
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