A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings
Autor: | Xueli Lv, Jin Zhang, Jingjing He, Tong Dongmei, Xiaochen Liu, Huanghao Yang, Jianxun Ding, Shumeng Bai, Ziwen Qiao, Hou Linxi, Shaohua He, Renjie Ruan |
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Rok vydání: | 2021 |
Předmět: |
Mussel-inspired hydrogel
QH301-705.5 0206 medical engineering Biomedical Engineering Fibroin macromolecular substances 02 engineering and technology Mussel inspired Article Biomaterials Chitosan Supramolecular cross-linking chemistry.chemical_compound Tannic acid Biology (General) Hemostatic function Materials of engineering and construction. Mechanics of materials Robust tissue anchor Tissue Adhesion Hemostatic sealant Sealant 021001 nanoscience & nanotechnology 020601 biomedical engineering chemistry Hemostasis TA401-492 0210 nano-technology Arterial and visceral bleeding models Biotechnology Biomedical engineering |
Zdroj: | Bioactive Materials Bioactive Materials, Vol 6, Iss 9, Pp 2829-2840 (2021) |
ISSN: | 2452-199X |
Popis: | In recent years, the developed hemostatic technologies are still difficult to be applied to the hemostasis of massive arterial and visceral hemorrhage, owing to their weak hemostatic function, inferior wet tissue adhesion, and low mechanical properties. Herein, a mussel-inspired supramolecular interaction-cross-linked hydrogel with robust mechanical property (308.47 ± 29.20 kPa) and excellent hemostatic efficiency (96.5% ± 2.1%) was constructed as a hemostatic sealant. Typically, we combined chitosan (CS) with silk fibroin (SF) by cross-linking them through tannic acid (TA) to maintain the structural stability of the hydrogel, especially for wet tissue adhesion ability (shear adhesive strength = 29.66 ± 0.36 kPa). Compared with other materials reported previously, the obtained CS/TA/SF hydrogel yielded a lower amount of blood loss and shorter time to hemostasis in various arterial and visceral bleeding models, which could be ascribed to the synergistic effect of wound closure under wet state as well as intrinsic hemostatic activity of CS. As a superior hemostatic sealant, the unique hydrogel proposed in this work can be exploited to offer significant advantages in the acute wound and massive hemorrhage with the restrictive access of therapeutic moieties. Graphical abstract Image 1 Highlights • A mussel-inspired supramolecular hydrogel is designed as a hemostatic sealant. • The biomimetic hydrogel presents robust wet tissue adhesion ability. • Wound closure and intrinsic hemostatic activity accelerate clotting synergistically. • The strategy realizes hemostasis of massive arterial and visceral hemorrhage. |
Databáze: | OpenAIRE |
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