The latex of Euphorbia tirucalli inhibits staphyloxanthin production and protects Tenebrio molitor larvae against Staphylococcus aureus infection
| Autor: | Michelle Russo Bendelak Uchoa, Thayná Fernandes Barros, Luís Cláudio Nascimento da Silva, Alexsander Rodrigues Carvalho Junior, Elizabeth S. Fernandes, Arthur Henrique Mendes Colasso, Isabella Fernandes da Silva Figueiredo |
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| Rok vydání: | 2019 |
| Předmět: |
Larva
biology 010405 organic chemistry Euphorbia tirucalli fungi Organic Chemistry Staphyloxanthin macromolecular substances Plant Science biology.organism_classification medicine.disease_cause 01 natural sciences Biochemistry In vitro 0104 chemical sciences Analytical Chemistry Microbiology 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry In vivo Staphylococcus aureus medicine |
| Zdroj: | Natural Product Research. 34:3536-3539 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | The latex of Euphorbia tirucalli L. (LET) has great etnopharmacological relevance for several traditional communities. In this study, the in vitro and in vivo (using Tenebrio molitor larvae) antimicrobial effects of LET were evaluated. LET did not inhibit the growth of S. aureus, however, a reduction on staphyloxanthin production (an important virulence factor of S. aureus) was observed. LET (at 10 μL/kg) was also able to enhance the survival of larvae infected with a lethal dose of S. aureus, an effect associated with reduction in the numbers of haemocytes. Furthermore, haemocytes from LET-treated larvae exhibited dysfunctional lysosome activity. These results indicate the effectiveness of LET as an anti-infective agent which could be useful as source of lead molecules for the development of new therapies against S. aureus-induced infections. |
| Databáze: | OpenAIRE |
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