Rectal absorption of E-2078 (dynorphin analogue peptide) in rats
| Autor: | Akira Kato, Naokazu Murahashi, Teruaki Yuzuriha, Noritoshi Koyama, Sumio Watanabe, Yasuo Miyake |
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| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Molecular Sequence Data Pharmaceutical Science Administration Oral Biological Availability Dynorphin Absorption (skin) Dynorphins Injections Subcutaneous injection Oral administration Administration Rectal Internal medicine medicine Animals Amino Acid Sequence Pharmacology Analgesics Osmotic concentration business.industry Viscosity Osmolar Concentration Rats Inbred Strains Hydrogen-Ion Concentration Peptide Fragments Rats Endocrinology Rectal Absorption Intestinal Absorption Rectal administration Intramuscular injection business |
| Zdroj: | The Journal of pharmacy and pharmacology. 41(11) |
| ISSN: | 0022-3573 |
| Popis: | The plasma levels in rats of a dynorphin analogue peptide (E-2078) after rectal administration have been studied. The bioavailabilities of E-2078 after rectal administration, subcutaneous injection, intramuscular injection, and oral administration were 21·6, 67·8, 67·1, 0·7%, respectively. The effect of dose, pH, osmolarity and viscosity on the rectal absorption of E-2078 were studied. A sigmoid relationship between the dose and the AUC was observed on rectal administration, while there was a linear relationship on intramuscular administration. The AUC was increased in acidic solution and highly viscous solution. The osmolarity did not affect the absorption of E-2078. In microscopic studies, E-2078 caused little or no damage to the rectal mucosa in rats. |
| Databáze: | OpenAIRE |
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