Biodistribution of liposome-entrapped human gamma-globulin
| Autor: | Maria E. Sarmiento, Maria de Los A Garcia-Santana, Maria A. Bécquer, Armando Acosta-Domínguez, María E. Lanio-Ruíz, Jorge Duconge, Luis Izquierdo |
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| Rok vydání: | 2006 |
| Předmět: |
Drug
Male Biodistribution media_common.quotation_subject Pharmaceutical Science Bronchi Pharmacology Iodine Radioisotopes chemistry.chemical_compound Mice Pharmacokinetics Phosphatidylcholine Medicine Animals Humans Pharmacology (medical) Tissue Distribution Administration Intranasal media_common Liposome Drug Carriers Mice Inbred BALB C business.industry Gamma globulin General Medicine Trachea chemistry Immunology Liposomes Nasal administration gamma-Globulins Drug carrier business |
| Zdroj: | Biopharmaceuticsdrug disposition. 27(6) |
| ISSN: | 0142-2782 |
| Popis: | The present study was aimed at the preparation and performance evaluation of Intacglobin®-loaded liposomes for selective drug presentation to the lungs. Egg phosphatidylcholine- and cholesterol-based liposomes (1:1 and 1:0.25 mol/mol) were prepared by a dehydration–rehydration procedure. A tissue distribution study after single intranasal administration of 0.5 µCi 125I-Intacglobin®-loaded liposomes was conducted in Balb/c mice. The efficiencies of drug entrapment (30%) and the average diameters did not differ significantly between the two liposome formulations. However, liposomes composed of an increased cholesterol amount showed a lower in vitro drug release rate. The airway penetration efficiency of the liposomal formulation was determined by the cumulative percentage of the dose reaching the lungs (AUC) and its sojourn time therein, and were 1.7- and 2.2-times higher compared with the plain 125I- Intacglobin® solution-based formulation, respectively. A significantly greater (p |
| Databáze: | OpenAIRE |
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