Efficacy of eye drops containing crosslinked hyaluronic acid and CoQ10 in restoring ocular health exposed to chlorinated water

Autor: Aldo Caporossi, Romina Fasciani, Antonio Villano, Gloria Gambini, Costanza Tredici
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Chlorinated water
genetic structures
Ubiquinone
medicine.medical_treatment
Administration
Ophthalmic

vitamin E
Pharmacology
Conjunctival Diseases
Corneal Diseases
chemistry.chemical_compound
0302 clinical medicine
Swimming Pools
Cornea
Surveys and Questionnaires
Hyaluronic acid
Prospective Studies
Hyaluronic Acid
Crosslinked hyaluronic acid
Chloramines
General Medicine
Vitamins
Drug Combinations
medicine.anatomical_structure
Cross-Linking Reagents
Adult
Ocular health
Conjunctiva
Clinical Trial Protocol
conjunctiva
Adolescent
chlorinated water
Hyperemia
03 medical and health sciences
Young Adult
coenzyme Q10
cornea
medicine
Humans
tear film
Coenzyme Q10
Vitamin E
Osmolar Concentration
eye diseases
Ophthalmology
030104 developmental biology
chemistry
Tears
030221 ophthalmology & optometry
Quality of Life
sense organs
Ophthalmic Solutions
ophthalmic solution
Water Pollutants
Chemical

Disinfectants
Zdroj: European Journal of Ophthalmology
ISSN: 1724-6016
1120-6721
Popis: Purpose: A prospective, open-label study in 20 professional swimmers evaluated the efficacy and safety of an ophthalmic solution containing crosslinked hyaluronic acid, coenzyme Q10, and vitamin E TPGS in releasing eye irritation and restoring ocular surface damages after prolonged exposure to chlorinated water. Methods: Individually, one eye was instilled with the ophthalmic solution and the other used as a comparator. Eye drops were self-administered three times a day for 2 months. Tear film breakup time (primary endpoint), Schirmer I test, beating of eyelashes/min, tear osmolarity, corneal and conjunctival staining with fluorescein, Ocular Surface Disease Index questionnaire, subject satisfaction, visual acuity (secondary endpoints), and Efron Grading Scale were evaluated at screening/baseline (V1), week 1 (V2), week 2 (V3), week 4 (V4), and week 8 (V5). Results: After 2 months, breakup time test significantly improved in the treated eyes (+1.67 s) compared to control (−3.00 s) ( p = 0.0002). Corneal and conjunctival surfaces of treated eyes recovered significantly compared to control eyes when assessed by fluorescein staining ( p Conclusion: The adequate combination of crosslinked hyaluronic acid, coenzyme Q10, and vitamin E TPGS, contained in the ophthalmic solution VisuXL®, has been shown to protect ocular surface from potential damages originating from prolonged exposure to chlorinated water. VisuXL may represent a compelling treatment in other situations beyond dry eye syndrome.
Databáze: OpenAIRE
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