Efficacy of eye drops containing crosslinked hyaluronic acid and CoQ10 in restoring ocular health exposed to chlorinated water
Autor: | Aldo Caporossi, Romina Fasciani, Antonio Villano, Gloria Gambini, Costanza Tredici |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Male Chlorinated water genetic structures Ubiquinone medicine.medical_treatment Administration Ophthalmic vitamin E Pharmacology Conjunctival Diseases Corneal Diseases chemistry.chemical_compound 0302 clinical medicine Swimming Pools Cornea Surveys and Questionnaires Hyaluronic acid Prospective Studies Hyaluronic Acid Crosslinked hyaluronic acid Chloramines General Medicine Vitamins Drug Combinations medicine.anatomical_structure Cross-Linking Reagents Adult Ocular health Conjunctiva Clinical Trial Protocol conjunctiva Adolescent chlorinated water Hyperemia 03 medical and health sciences Young Adult coenzyme Q10 cornea medicine Humans tear film Coenzyme Q10 Vitamin E Osmolar Concentration eye diseases Ophthalmology 030104 developmental biology chemistry Tears 030221 ophthalmology & optometry Quality of Life sense organs Ophthalmic Solutions ophthalmic solution Water Pollutants Chemical Disinfectants |
Zdroj: | European Journal of Ophthalmology |
ISSN: | 1724-6016 1120-6721 |
Popis: | Purpose: A prospective, open-label study in 20 professional swimmers evaluated the efficacy and safety of an ophthalmic solution containing crosslinked hyaluronic acid, coenzyme Q10, and vitamin E TPGS in releasing eye irritation and restoring ocular surface damages after prolonged exposure to chlorinated water. Methods: Individually, one eye was instilled with the ophthalmic solution and the other used as a comparator. Eye drops were self-administered three times a day for 2 months. Tear film breakup time (primary endpoint), Schirmer I test, beating of eyelashes/min, tear osmolarity, corneal and conjunctival staining with fluorescein, Ocular Surface Disease Index questionnaire, subject satisfaction, visual acuity (secondary endpoints), and Efron Grading Scale were evaluated at screening/baseline (V1), week 1 (V2), week 2 (V3), week 4 (V4), and week 8 (V5). Results: After 2 months, breakup time test significantly improved in the treated eyes (+1.67 s) compared to control (−3.00 s) ( p = 0.0002). Corneal and conjunctival surfaces of treated eyes recovered significantly compared to control eyes when assessed by fluorescein staining ( p Conclusion: The adequate combination of crosslinked hyaluronic acid, coenzyme Q10, and vitamin E TPGS, contained in the ophthalmic solution VisuXL®, has been shown to protect ocular surface from potential damages originating from prolonged exposure to chlorinated water. VisuXL may represent a compelling treatment in other situations beyond dry eye syndrome. |
Databáze: | OpenAIRE |
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