Electroacupuncture Alleviates Chronic Pain-Induced Anxiety Disorders by Regulating the rACC-Thalamus Circuitry
| Autor: | Jianqiao Fang, Zui Shen, Boyi Liu, Shujing Yao, Ye-Qing Chen, Jing Sun, Junfan Fang, Chi Xu, Junying Du, Yingling Xu, Haiyan Zhang, Xixiao Zhu, Zemin Wu, Qiaoying He, Xiaomei Shao, Yuanyuan Wu, Xiaofen He, Yongliang Jiang, Mengwei Wu, Yi Liang, Jinggen Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Electroacupuncture
medicine.medical_treatment Thalamus Rat model lcsh:RC321-571 Glutamatergic thalamus electroacupuncture Medicine circuitry pain-related anxiety lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Anterior cingulate cortex Original Research business.industry General Neuroscience Chronic pain medicine.disease Comorbidity medicine.anatomical_structure rostral anterior cingulate cortex Anxiety medicine.symptom business chronic pain Neuroscience |
| Zdroj: | Frontiers in Neuroscience, Vol 14 (2021) Frontiers in Neuroscience |
| DOI: | 10.3389/fnins.2020.615395/full |
| Popis: | Anxiety is a common comorbidity associated with chronic pain, which results in chronic pain complexification and difficulty in treatment. Electroacupuncture (EA) is commonly used to treat chronic pain and anxiety. However, the underlying mechanisms of the EA effect are largely unknown. Here, we showed that a circuitry underlying chronic pain induces anxiety disorders, and EA can treat them by regulating such circuitry. Using chemogenetic methods, we found that chemogenetic activation of the rostral anterior cingulate cortex (rACC) glutamatergic output to the thalamus induced anxiety disorders in control rats. Then, chemogenetic inhibition of the rACC-thalamus circuitry reduced anxiety-like behavior produced by intraplantar injection of the complete Freund’s adjuvant (CFA). In this study, we examined the effects of EA on a rat model of CFA-mediated anxiety-like behaviors and the related mechanisms. We found that chemogenetic activation of the rACC-thalamus circuitry effectively blocked the effects of EA on chronic pain-induced anxiety-like behaviors in CFA rats. These results demonstrate an underlying rACC-thalamus glutamatergic circuitry that regulates CFA-mediated anxiety-like behaviors. This study also provides a potential mechanistic explanation for EA treatment of anxiety caused by chronic pain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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