Examining the Relative Contributions of Methamphetamine Use, Depression, and Sexual Risk Behavior on Rectal Gonorrhea/Chlamydia Among a Cohort of Men Who Have Sex With Men in Los Angeles, California

Autor: Cheríe S Blair, Steven Shoptaw, Robert K. Bolan, Marjan Javanbakht, W. Scott Comulada, Pamina M. Gorbach, Jack Needleman, Amy Ragsdale
Rok vydání: 2023
Předmět:
Microbiology (medical)
Male
medicine.medical_treatment
Sexual Behavior
Sexually Transmitted Diseases
HIV Infections
Sexual and Gender Minorities (SGM/LGBT*)
Dermatology
Medical and Health Sciences
Article
Men who have sex with men
Methamphetamine
Gonorrhea
Sexual and Gender Minorities
Risk-Taking
Clinical Research
Behavioral and Social Science
Medicine
Humans
Chlamydia
Homosexuality
Male
Sexual risk
Depression (differential diagnoses)
Pediatric
business.industry
Depression
Prevention
Public Health
Environmental and Occupational Health
Homosexuality
Biological Sciences
Chlamydia Infections
medicine.disease
Los Angeles
Stimulant
Mental Health
Good Health and Well Being
Infectious Diseases
Sexual Partners
Methamphetamine use
Cohort
Rectal gonorrhea
HIV/AIDS
Sexually Transmitted Infections
Public Health
Infection
business
Demography
Zdroj: Sex Transm Dis
Sexually transmitted diseases, vol 49, iss 3
ISSN: 1537-4521
Popis: BackgroundMethamphetamine use, sexual risk behaviors, and depression contribute to ongoing human immunodeficiency virus (HIV) and sexually transmitted infection (STI) disparities among men who have sex with men (MSM). The relative contributions of these effects longitudinally are not well understood.MethodsThis analysis used visit-level data from a longitudinal cohort of MSM, half with HIV, in Los Angeles, CA. From August 2014 to March 2020, participants completed follow-up visits every 6 months and underwent testing for rectal gonorrhea/chlamydia (GC/CT) and completed questionnaires including depressive symptoms, number of receptive anal intercourse (RAI) partners, and methamphetamine use. Path analysis with structural equation modeling using concurrent and lagged covariates was used to identify relative contributions of methamphetamine use and depression on number of RAI partners and rectal GC/CT across time.ResultsFive hundred fifty-seven MSM with up to 6 visits (3 years) were included for a total of 2437 observations. Methamphetamine use and depressive symptoms were positively associated with number of RAI partners (β = 0.28, P < 0.001; β = 0.33, P = 0.018, respectively), which was positively associated with rectal GC/CT (β = 0.02, P < 0.001). When stratified by HIV status, depressive symptoms were positively associated with RAI partners for HIV-negative MSM (β = 0.50, P = 0.007) but were not associated for MSM living with HIV (β = 0.12, P = 0.57). Methamphetamine use was positively associated with RAI partners in both strata.ConclusionsFactors and patterns, which contribute to risk behaviors associated with rectal GC/CT, may differ by HIV status. Our findings demonstrate the importance of combined treatment and prevention efforts that link screening and treatment of stimulant use and depression with STI prevention and treatment.
Databáze: OpenAIRE
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