QEEG alpha 1 changes after a single dose of high-potency neuroleptics as a predictor of short-term response to treatment in schizophrenic patients
| Autor: | Dargut Kemali, Armida Mucci, Silvana Galderisi, Mario Maj, Paola Bucci |
|---|---|
| Přispěvatelé: | Galderisi, Silvana, Maj, Mario, Mucci, Armida, Bucci, Paola, Kemali, D. |
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Test dose Adolescent Electroencephalography Clopenthixol medicine Haloperidol Humans Potency Psychiatry Biological Psychiatry Psychiatric Status Rating Scales Dose-Response Relationship Drug medicine.diagnostic_test Brain Middle Aged medicine.disease Response to treatment Treatment Outcome Schizophrenia Anesthesia Female Psychology medicine.drug |
| Popis: | Baseline quantitative electroencephalographic (QEEG) characteristics and their changes after a single test dose of either haloperidol or clopenthixol were investigated in a group of 29 schizophrenics as possible predictors of short-term response to those drugs. On baseline QEEG assessment, responders (R) to subsequent treatment showed fewer slow and more fast activities than nonresponders (NR). A large overlap between R and NR with respect to these measures was observed, however, revealing their practical inadequacy to predict short-term response in individual patients. On the contrary, changes in alpha1, observed 6 hr after the administration of a single test dose of either haloperidol or clopenthixol, discriminated to a very large extent between R and NR, correctly identifying 17 out of 18 R and 8 out of 10 NR. The QEEG test dose procedure might be used in the selection of the most appropriate antipsychotic drug for individual schizophrenic patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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