Prevalência, fatores de risco e caracterização genética dos vírus linfotrópico de células T humana tipo 1 e 2 em pacientes infectados pelo vírus da imunodeficiência humana tipo 1 nas Cidades de Ribeirão Preto e São Paulo
| Autor: | Ester Cerdeira Sabino, Sabri Saeed Sanabani, Leda Fátima Jamal, Walter Kleine Neto |
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| Rok vydání: | 2009 |
| Předmět: |
Vírus linfotrópico de células T humana tipo 2
Microbiology (medical) Vírus linfotrópico de células T humana tipo 1 viruses Hepatitis C virus Population Prevalence medicine.disease_cause law.invention Vírus da imunodeficiência humana tipo 1 immune system diseases law hemic and lymphatic diseases medicine Prevalência education Polymerase chain reaction Hepatitis education.field_of_study Fatores de risco biology business.industry Transmission (medicine) virus diseases Hepatitis C medicine.disease Virology Infectious Diseases Immunology biology.protein Parasitology Antibody business |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical v.42 n.3 2009 Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
| ISSN: | 0037-8682 |
| DOI: | 10.1590/s0037-86822009000300006 |
| Popis: | The aim of this study was to define the prevalence of human T cell lymphotropic virus types 1 and 2 in patients who were positive for human immunodeficiency virus type 1 in the State of Sao Paulo, Brazil. We evaluated 319 individuals infected with HIV type 1 who were attended at specialized clinics in two cities (Ribeirao Preto and Sao Paulo). The patients were interviewed and tested for antibodies against HTLV types 1 and 2 (Orthoâ HTLV-1/HTLV-2 Ab-Capture enzyme immunoassay). Direct DNA sequencing of polymerase chain reaction products from the tax region of HTLV type 2 and the long terminal repeat region of HTLV types 1 and 2 were performed to differentiate and determine the subtypes. The overall prevalence of anti-HTLV type 1 and 2 antibodies was 7.5% (24/319; 95% CI: 5.2-11.5). HTLV type 1 and 2 infection was associated with a history of injected drug use and with antibodies for hepatitis C virus (p 0.05). HTLV DNA was detected in 13 out of 24 samples, of which 12 were characterized as HTLV subtype 2c and one as HTLV subtype 1a. Among the 12 HTLV type 2 samples, seven were from injected drug users, thus indicating that this route is an important risk factor for HTLV type 2 transmission among our population infected with HIV type 1. |
| Databáze: | OpenAIRE |
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