Porogens in the preparation of microporous hydrogels based on poly(ethylene oxides)
| Autor: | Manohar V. Badiger, Marion E. McNeill, Neil B. Graham |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Magnetic Resonance Spectroscopy
Materials science Proxyphylline Polyurethanes Biophysics Biocompatible Materials Bioengineering macromolecular substances complex mixtures Polyethylene Glycols Diffusion Biomaterials chemistry.chemical_compound Differential scanning calorimetry Theophylline PEG ratio Polymer chemistry Calorimetry Differential Scanning Ethylene oxide technology industry and agriculture Microporous material Aminophylline Controlled release Molecular Weight Vitamin B 12 chemistry Chemical engineering Mechanics of Materials Delayed-Action Preparations Self-healing hydrogels Ceramics and Composites Spectrophotometry Ultraviolet Gels Porosity Ethylene glycol |
| Zdroj: | Biomaterials. 14:1059-1063 |
| ISSN: | 0142-9612 |
| Popis: | To enable the synthesis of hydrogels containing microporosity, a family of pore generating additives (porogens) were synthesized from poly(ethylene glycols) (PEGs) with different molecular weights using naphthyl acetic acid. The products formed were characterized by UV-vis, differential scanning calorimetry and solution nuclear magnetic resonance techniques. Subsequently, poly(ethylene oxide)-urethane hydrogels were synthesized incorporating the above mentioned PEG porogens to modify the structure of the hydrogel. These highly water soluble PEG porogens were inert and extracted out in water. The hydrogels obtained exhibited significant increase in the equilibrium water uptake. This was attributed to the formation of a microporous structure in the hydrogel. It was also evidenced by the observed increase in the diffusion coefficients of the drugs proxyphylline and vitamin B12 through this hydrogel. The proportional increase was greater for the higher molecular weight vitamin B12 than for the proxyphylline. These results may be useful in developing porous hydrogels for controlled release technology. |
| Databáze: | OpenAIRE |
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