Involvement of the N -Methyl D-Aspartate (NMDA) Receptor in Synapse Elimination During Cerebellar Development
| Autor: | Jean Mariani, Rabacchi Sylvia A, Nicole Delhaye-Bouchaud, Yannick Bailly |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cerebellum
medicine.medical_specialty Central nervous system Biology Synapse Purkinje Cells In vivo Internal medicine medicine Animals Multidisciplinary Glutamate receptor Climbing fiber Rats Receptors Neurotransmitter Electrophysiology medicine.anatomical_structure Endocrinology 2-Amino-5-phosphonovalerate Animals Newborn Receptors Glutamate nervous system Synapses Silent synapse NMDA receptor Neuroscience |
| Zdroj: | Science. 256:1823-1825 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1352066 |
| Popis: | In many instances, the establishment of highly specific neuronal connections during development results from the rearrangement of axonal projections through the trimming of exuberant collaterals or the elimination of functional synapses or both. Although the involvement of the N-methyl D-aspartate (NMDA) subtype of the glutamate receptor has been demonstrated in the shaping of axonal arbors, its participation in the process of selective stabilization of synapses remains an open issue. In this study, the effects of chronic in vivo application of D,L-2-amino-5-phosphonovaleric acid (D,L-APV), a selective antagonist of the NMDA receptor, on the synapse elimination process that takes place in the developing cerebellum of the rat have been analyzed. D,L-APV treatment prevented the regression of supernumerary climbing fiber synapses in 49 percent of the recorded Purkinje cells, while the inactive isomer L-APV was ineffective. Thus, activation of the NMDA receptor is a critical step in the regression of functional synapses during development. |
| Databáze: | OpenAIRE |
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