The Structure of a New Sialic Acid-Containing Decasaccharide from the Urine of a Patient with Mucolipidosis
| Autor: | Masai Koseki, Koichi Tsurumi |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Chemical Phenomena
Silicic Acid Oligosaccharides Mannose Biology Methylation General Biochemistry Genetics and Molecular Biology Excretion chemistry.chemical_compound Mucolipidoses Methods medicine Humans Glycoside hydrolase chemistry.chemical_classification Mucolipidosis General Medicine Oligosaccharide Silicon Dioxide medicine.disease Sialic acid Chemistry Biochemistry chemistry Galactose Glycoprotein |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 128:39-49 |
| ISSN: | 1349-3329 0040-8727 |
| DOI: | 10.1620/tjem.128.39 |
| Popis: | A new sialic acid-containing oligosaccharide has been isolated from urine of a patient with a type of mucolipidosis newly recognized by Orii et al. (1972). This compound was found to be composed of galactose (2 moles), mannose (3 moles), N-acetylglucosamine (3 moles) and sialic acid (2 moles). On the basis of the results of sequential glycosidase digestion, of methylation analysis, and of the Smith degradation, the structure of this oligosaccharide was elucidated as follows: NeuAcalpha2-6Galbeta1-4GlcNAcbeta1-2Manalpha1-3[NeuAcalpha2-6Galbeta1-4GlcNAcbeta1-2Manalpha1-6]Manbeta1-4GlcNAc. The increased excretion of this oligosaccharide may be caused by the impaired metabolism of glycoproteins having N-glycosidic linkage. |
| Databáze: | OpenAIRE |
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