Prognostic value of cardiac biomarkers in COVID-19 infection
| Autor: | Aakash Sheth, Paari Dominic, Malak Modi, Desiree Dawson |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Science Critical Illness Cardiology 030204 cardiovascular system & hematology Article Fibrin Fibrinogen Degradation Products Prognostic markers 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology Natriuretic Peptide Brain Medicine Humans 030212 general & internal medicine Prospective Studies Prospective cohort study Creatine Kinase Retrospective Studies Multidisciplinary biology L-Lactate Dehydrogenase SARS-CoV-2 business.industry Myocardium Respiratory infection COVID-19 Retrospective cohort study Odds ratio Prognosis Troponin Confidence interval Peptide Fragments Cardiovascular Diseases Meta-analysis biology.protein business Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Multiple Biomarkers have recently been shown to be elevated in COVID-19, a respiratory infection with multi-organ dysfunction; however, information regarding the prognostic value of cardiac biomarkers as it relates to disease severity and cardiac injury are inconsistent. The goal of this meta-analysis was to summarize the evidence regarding the prognostic relevance of cardiac biomarkers from data available in published reports. PubMed, Embase and Web of Science were searched from inception through April 2020 for studies comparing median values of cardiac biomarkers in critically ill versus non-critically ill COVID-19 patients, or patients who died versus those who survived. The weighted mean differences (WMD) and 95% confidence interval (CI) between the groups were calculated for each study and combined using a random effects meta-analysis model. The odds ratio (OR) for mortality based on cardiac injury was combined from studies reporting it. Troponin levels were significantly higher in COVID-19 patients who died or were critically ill versus those who were alive or not critically ill (WMD 0.57, 95% CI 0.43–0.70, p |
| Databáze: | OpenAIRE |
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