An observational study on disturbed peripheral circadian rhythms in hemodialysis patients
| Autor: | Kira F. Dorsman, Birgit C. P. Koch, Ido P. Kema, Carlo A. J. M. Gaillard, Karolina Lech, Manfred Kayser, Marije Russcher, Inês Chaves, H. van Faassen, J. Elsbeth Nagtegaal, Gijsbertus T. J. van der Horst, Anke ’t Jong |
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| Přispěvatelé: | Guided Treatment in Optimal Selected Cancer Patients (GUTS), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Molecular Genetics, Genetic Identification, Pharmacy |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty MELATONIN Hydrocortisone Physiology Circadian clock CLOCK PERIOD Excessive daytime sleepiness Biology cortisol Cell Line End stage renal disease Melatonin KIDNEY Renal Dialysis Sleep Disorders Circadian Rhythm Surveys and Questionnaires Physiology (medical) Internal medicine clock synchronization medicine clock genes Humans Prospective Studies Circadian rhythm Fatigue Aged GENE-EXPRESSION end-stage renal disease hemodialysis Gene Expression Profiling Middle Aged SLEEP Circadian Rhythm VARIABILITY MICE Endocrinology Quality of Life Kidney Failure Chronic Female Sleep onset latency medicine.symptom Sleep onset Biomarkers medicine.drug |
| Zdroj: | Chronobiology International, 32(6), 848-857. Taylor & Francis Group Chronobiology International, 32(6), 848-857. Informa Healthcare |
| ISSN: | 1525-6073 0742-0528 |
| Popis: | The quality of life of hemodialysis (HD) patients is hampered by reduced nocturnal sleep quality and excessive daytime sleepiness. In addition to the sleep/wake cycle, levels of circadian biomarkers (e.g. melatonin) are disturbed in end-stage renal disease (ESRD). This suggests impaired circadian clock performance in HD patients, but the underlying mechanism is unknown. In this observational study, diurnal rhythms of sleep, serum melatonin and cortisol concentrations and clock gene mRNA expression are compared between HD patients (n = 9) and healthy control subjects (n = 9). In addition, the presence of circulating factors that might affect circadian rhythmicity is tested in vitro with cell culture experiments. Reduced sleep quality (median sleep onset latency [interquartile range] of 23.9 [17.3] min for patients versus 5.0 [10] minutes for controls, p |
| Databáze: | OpenAIRE |
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