Hydroxyapatite-poly(d,l-lactide) Nanografts. Synthesis and Characterization as Bone Cement Additives
| Autor: | Ivan Gitsov, Kristina L. Goranova, Anne Kathrine Kattenhøj Sloth Overgaard |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
010407 polymers
Materials science Polymers ring-opening polymerization Pharmaceutical Science Biocompatible Materials 02 engineering and technology polyesters 01 natural sciences Ring-opening polymerization Catalysis Article Analytical Chemistry Polymerization lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Drug Discovery Physical and Theoretical Chemistry Thermal analysis chemistry.chemical_classification bone cement Lactide Organic Chemistry Bone Cements hydroxyapatite Polymer 021001 nanoscience & nanotechnology Bone cement Grafting 0104 chemical sciences Nanostructures Polyester Molecular Weight Durapatite Chemical engineering chemistry Chemistry (miscellaneous) Molecular Medicine lactide 0210 nano-technology biomaterials |
| Zdroj: | Molecules, Vol 26, Iss 424, p 424 (2021) Molecules Volume 26 Issue 2 |
| ISSN: | 1420-3049 |
| Popis: | This paper reports the creation of hydroxyapatite/polyester nanografts by &ldquo graft-from&rdquo polymerization of d,l-lactide with [Ca5(OH)(PO4)3]2 as the initiator and tin(II)-2-ethylhexanoate as the catalyst. Model polymerizations were performed with cyclooctanol as initiator to confirm the grafting on the surface of the hydroxyapatite nanocrystals. Polymers with the highest molecular mass (Mn) between 4250 Da (cyclooctanol) and 6100 Da (hydroxyapatite) were produced. In both cases the molecular mass distributions of the polymers formed were monomodal. The materials obtained were characterized by size-exclusion chromatography, NMR and FT-IR spectroscopy, and thermal methods. Their suitability as additives for commercial bone cement (Simplex P Speedset, Stryker Orthopaedics) has been confirmed by thermal analysis techniques and mechanical testing. The results obtained show that addition of the hydroxyapatite/ polyester nanografts improved both thermal and mechanical properties of the bone cement. |
| Databáze: | OpenAIRE |
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