Anti-HBV activities of Streblus asper and constituents of its roots
| Autor: | Mao-Tong Tang, Jian Li, Xiao-Jian Su, Xin-Lan Guan, Rui-Yun Yang, Hong Chen, Qiang Wu, Xiao-Tao Niu, Jun Li, Sheng-Ping Deng |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Honokiol
Hepatitis B virus Stereochemistry Ethyl acetate Streblus asper Antiviral Agents Moraceae Plant Roots Lignans Inhibitory Concentration 50 chemistry.chemical_compound Drug Discovery Humans Pharmacology Lignan Molecular Structure biology Traditional medicine Plant Extracts Chemistry Biphenyl Compounds virus diseases Hep G2 Cells General Medicine Carbon-13 NMR Hepatitis B biology.organism_classification digestive system diseases Lamivudine Proton NMR Plant Structures Two-dimensional nuclear magnetic resonance spectroscopy Phytotherapy |
| Zdroj: | Fitoterapia. 83:643-649 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2012.01.009 |
| Popis: | The extracts from leaves, heartwood, barks and roots of the Streblus asper were investigated for anti-HBV activities, separately. The results suggested that the MeOH extracts of the heartwood, barks, and roots exhibited good anti-HBV activities. Further investigations displayed that ethyl acetate and n-butanol soluble parts of their MeOH extracts showed more significant anti-HBV activities. Moreover, a new lignan, together with 11 known compounds, was isolated from n-butanol-soluble part of MeOH extract of the roots of S. asper. The structures were elucidated by spectroscopic methods, including 1D NMR ((1)H NMR, (13)C NMR), 2D NMR (HMQC, HMBC) and HR-EI-MS experiments. Compounds 1-3 were evaluated for their anti-HBV activities. Honokiol showed significant anti-HBV activity with IC(50) values of 3.14μM and 4.74μM for HBsAg and HBeAg with no cytotoxicity respectively, while lamivudine (3TC, positive control) exhibited weak anti-HBV activity with IC(50) values of 11.81μM and 25.80μM for HBsAg and HBeAg respectively. |
| Databáze: | OpenAIRE |
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