Addiction potential of phentermine prescribed during long-term treatment of obesity
| Autor: | C L Mitchell, Y Istratiy, S Souter, M J Hendricks, Manit Srisurapanont, Frank L. Greenway, M Haggard, Stacy L. Schmidt, D G De Marco, Ed J. Hendricks |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Topiramate Phentermine medicine.medical_specialty Time Factors Long term treatment Substance-Related Disorders Endocrinology Diabetes and Metabolism media_common.quotation_subject Medicine (miscellaneous) Drug Administration Schedule Elevated blood Surveys and Questionnaires Generic drug Appetite Depressants Weight Loss medicine Humans Obesity Psychiatry Aged media_common Aged 80 and over Nutrition and Dietetics United States Food and Drug Administration business.industry Addiction Middle Aged medicine.disease United States Behavior Addictive Anesthesia Female Guideline Adherence Addictive behavior business medicine.drug |
| Zdroj: | International Journal of Obesity. 38:292-298 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/ijo.2013.74 |
| Popis: | To investigate if phentermine treatment induces phentermine abuse, psychological dependence (addiction) or phentermine drug craving in overweight, obese and weight loss maintenance patients. To investigate whether amphetamine-like withdrawal occurs after abrupt cessation of long-term phentermine treatment.Clinical intervention trial with interruption of phentermine treatment in long-term patients.269 obese, overweight or formerly obese subjects (age: 20-88 years, BMI: 21-74 kg m(-2)) treated with phentermine long-term (LTP, N=117), 1.1-21.1 years, or short-term (ATP, N=152), 4-22 days, with phentermine doses of 18.75-112.5 (LTP) and 15-93.75 (ATP) mg per day.Module K of the Mini International Neuropsychiatric Interview modified for phentermine (MINI-SUD), Severity of Dependence Scale (SDS), 45-item Cocaine Craving Questionnaire-NOW (CCQ-NOW) modified for phentermine (PCQ-NOW), and Amphetamine Withdrawal Questionnaire (AWQ) modified for phentermine (PWQ).MINI-SUD interviews were negative for phentermine abuse or psychological dependence in all LTP patients. SDS examination scores were low for all LTP and ATP patients, indicating they were not psychologically dependent upon phentermine. PCQ-NOW scores were low for all LTP and ATP patients, indicating neither short-term nor long-term phentermine treatment had induced phentermine craving. Other than an increase in hunger or eating, amphetamine-like withdrawal symptoms did not occur upon abrupt phentermine cessation as measured by sequential PWQ scores.Phentermine abuse or psychological dependence (addiction) does not occur in patients treated with phentermine for obesity. Phentermine treatment does not induce phentermine drug craving, a hallmark sign of addiction. Amphetamine-like withdrawal does not occur upon abrupt treatment cessation even at doses much higher than commonly recommended and after treatment durations of up to 21 years. |
| Databáze: | OpenAIRE |
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