Hippocampal neuronal loss, decreased GFAP immunoreactivity and cognitive impairment following experimental intoxication of rats with aluminum citrate
| Autor: | Natalino Valente Moreira de Siqueira, Maria Socorro Aguiar, Rafael Rodrigues Lima, Edna Cristina S. Franco, Lilian Rosana Ferreira Faro, Walace Gomes-Leal, Luana N. S. Santana, Romulo Augusto Feio, Ademir F Junior Silva, Odemir S Junior Carvalho |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Survival Neuroscience(all) Clinical Neurology Anxiety Motor Activity Hippocampal formation Hippocampus Citric Acid Open field chemistry.chemical_compound Memory Internal medicine Glial Fibrillary Acidic Protein Sodium citrate Avoidance Learning medicine Aluminum citrate Animals Hippocampus (mythology) Learning Rats Wistar Maze Learning Molecular Biology Neurons Analysis of Variance Memory Disorders Learning Disabilities business.industry General Neuroscience Immunohistochemistry Rats Endocrinology medicine.anatomical_structure chemistry nervous system Anesthesia Astrocytes Neurotoxicity Syndromes Neurology (clinical) Analysis of variance Cognition Disorders business Citric acid Psychomotor Performance Astrocyte Developmental Biology |
| Zdroj: | Brain Research. 1491:23-33 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2012.10.063 |
| Popis: | Aluminum (Al) is a neurotoxic agent with deleterious actions on cognitive processes. Nevertheless, few studies have investigated the neuropathological effects underling the Al-induced cognitive impairment. We have explored the effects of acute Al citrate intoxication on both hippocampal morphology and mnemonic processes in rodents. Adult male Wistar rats were intoxicated with a daily dose of Al citrate (320mg/kg) during 4 days by gavage. Animals were perfused at 8 (G2), 17 (G3) and 31 days (G4) after intoxication. Control animals were treated with sodium citrate (G1). Animals were submitted to behavioral tests of open field and elevated T-maze. Immunohistochemistry was performed to label neurons (anti-NeuN) and astrocytes (anti-GFAP) in both CA1 and CA3 hippocampal regions. There was an increase in the locomotor activity in open field test for G2 in comparison to control group and other groups (ANOVA-Bonferroni, P |
| Databáze: | OpenAIRE |
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