Association of MICA gene polymorphisms with liver fibrosis in schistosomiasis patients in the Dongting Lake region
| Autor: | Ping Yu, Shi-Ping Wang, Yu-Ping Su, Qizhi Luo, Hai-Bo Peng, Zheng Gong, Kun Du, Lin Lin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Liver Cirrhosis
Male Physiology Severity of Illness Index Biochemistry Schistosoma japonicum NKG2D Cohort Studies Gene Frequency Genotype Schistosomiasis General Pharmacology Toxicology and Pharmaceutics lcsh:QH301-705.5 Aged 80 and over lcsh:R5-920 biology General Neuroscience Gene polymorphism General Medicine Middle Aged Female lcsh:Medicine (General) Adult China Short Communication Immunology Liver fibrosis Biophysics Major histocompatibility complex medicine Humans Genetic Predisposition to Disease Allele Allele frequency Aged Schistosoma Polymorphism Genetic Histocompatibility Antigens Class I Cell Biology medicine.disease biology.organism_classification stomatognathic diseases lcsh:Biology (General) Case-Control Studies MICA biology.protein |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Volume: 45, Issue: 3, Pages: 222-229, Published: MAR 2012 Brazilian Journal of Medical and Biological Research v.45 n.3 2012 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Vol 45, Iss 3, Pp 222-229 (2012) |
| Popis: | Major histocompatibility complex class I chain-related A (MICA) is a highly polymorphic gene located within the MHC class I region of the human genome. Expressed as a cell surface glycoprotein, MICA modulates immune surveillance by binding to its cognate receptor on natural killer cells, NKG2D, and its genetic polymorphisms have been recently associated with susceptibility to some infectious diseases. We determined whether MICA polymorphisms were associated with the high rate of Schistosoma parasitic worm infection or severity of disease outcome in the Dongting Lake region of Hunan Province, China. Polymerase chain reaction-sequence specific priming (PCR-SSP) and sequencing-based typing (SBT) were applied for high-resolution allele typing of schistosomiasis cases (N = 103, age range = 36.2-80.5 years, 64 males and 39 females) and healthy controls (N = 141, age range = 28.6-73.3 years, 73 males and 68 females). Fourteen MICA alleles and five short-tandem repeat (STR) alleles were identified among the two populations. Three (MICA*012:01/02, MICA*017 and MICA*027) showed a higher frequency in healthy controls than in schistosomiasis patients, but the difference was not significantly correlated with susceptibility to S. japonicum infection (Pc > 0.05). In contrast, higher MICA*A5 allele frequency was significantly correlated with advanced liver fibrosis (Pc < 0.05). Furthermore, the distribution profile of MICA alleles in this Hunan Han population was significantly different from those published for Korean, Thai, American-Caucasian, and Afro-American populations (P < 0.01), but similar to other Han populations within China (P > 0.05). This study provides the initial evidence that MICA genetic polymorphisms may underlie the severity of liver fibrosis occurring in schistosomiasis patients from the Dongting Lake region. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|