Repair of critical size defects in the rat cranium using ceramic-reinforced PLA scaffolds obtained by supercritical gas foaming
| Autor: | Silke Mark, Dominique P. Pioletti, L. Mathieu, Pierre-Yves Zambelli, Pierre-Etienne Bourban, M.O. Montjovent, Lee Ann Laurent-Applegate, Hugo G. Schmoekel |
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| Rok vydání: | 2007 |
| Předmět: |
Ceramics
Scaffold skull defects Polymers implants Biocompatible Materials scaffold Rats Sprague-Dawley chemistry.chemical_compound Implants Experimental bone regeneration Polylactic acid Tissue engineering Ceramic bone tissue engineering polylactic acid Metals and Alloys growth-factor delivery visual_art visual_art.visual_art_medium Cytokines cranioplasty lipids (amino acids peptides and proteins) Gases Materials science Biocompatibility Polyesters Biomedical Engineering in-vitro Biomaterials biocompatibility In vivo Animals Lactic Acid Bone regeneration Wound Healing model Tissue Engineering Body Weight Skull Supercritical fluid Blood Cell Count Rats Radiography chemistry Bone Substitutes Ceramics and Composites composite scaffolds bioresorbable composites Biomedical engineering |
| Zdroj: | Journal of Biomedical Materials Research Part A. :41-51 |
| ISSN: | 1552-4965 1549-3296 |
| Popis: | Bioresorbable scaffolds made Of poly(L-lactic acid) (PLA) obtained by supercritical gas foaming were recently described as suitable for tissue engineering, portraying biocompatibility with primary osteoblasts in vitro and interesting mechanical properties when reinforced with ceramics. The behavior of such constructs remained to be evaluated in vivo and therefore the present study was undertaken to compare different PLA/ceramic composite scaffolds obtained by supercritical gas foaming in a critical size defect craniotomy model in Sprague-Dawley rats. The host-tissue reaction to the implants was evaluated semiquantitatively and similar tendencies were noted for all graft substitutes: initially highly reactive but decreasing with time implanted. Complete bone-bridging was observed IS weeks after implantation with PLA/ 5 wt % beta-TCP (PLA/TCP) and PLA/5 wt % HA (PLA/HA) scaffolds as assessed by histology and radiography. We show here for the first time that this solvent-free technique provides a promising approach in tissue engineering demonstrating both the biocompatibility and osteoconcluctivity of the processed structures in vivo. |
| Databáze: | OpenAIRE |
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