Effects of Aspirin During Exercise on the Incidence of High-Altitude Headache: A Randomized, Double-Blind, Placebo-Controlled Trial
| Autor: | Rudolf Likar, Martin Burtscher, Reinhard Pühringer, Werner Nachbauer, Thomas Lämmle, Michael Philadelphy |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Placebo-controlled study Physical exercise Altitude Sickness Placebo law.invention Double-Blind Method Randomized controlled trial law Heart rate medicine Humans Exercise Aspirin business.industry Altitude Incidence Headache Middle Aged Effects of high altitude on humans Mountaineering Oxygen Blood pressure Neurology Anesthesia Acute Disease Female Neurology (clinical) business medicine.drug |
| Zdroj: | Headache: The Journal of Head and Face Pain. 41:542-545 |
| ISSN: | 1526-4610 0017-8748 |
| DOI: | 10.1046/j.1526-4610.2001.041006542.x |
| Popis: | Objective.—To evaluate the efficacy of aspirin for headache when exercising during acute high-altitude exposure. Background.—Aspirin effectively prevents headache when mostly resting during acute high-altitude exposure. However, the majority of individuals exposed to high altitude perform mountaineering activities, which might trigger headache. Design.—Randomized, double-blind, placebo-controlled trial. Methods.—Thirty-one healthy volunteers (20 men, 11 women; aged 22 to 59 years) were transported to an altitude of about 3000 meters and climbed up to 3800 meters. They then descended to a mountain hut at 3480 meters and spent 2 nights there. Tablets (placebo or 320 mg aspirin) were administered three times at 4-hour intervals, beginning 2 hours before arrival at high altitude. Headache scoring and measurements of heart rate, blood pressure, and arterial oxygen saturation were performed. Results.—Ninety-three percent (14 of 15) of the placebo group and 56% (9 of 16) of the aspirin group developed headache when mountaineering activities were performed during acute exposure to high altitude (P |
| Databáze: | OpenAIRE |
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