Technetium mixed-ligand complexes containing bidentate phosphines and monodentate thiol ligands. Preparation, in vitro data and detection of a certain heart affinity
| Autor: | Sonja Abram, Rudolf Münze, Gudrun Kampf, Ulrich Abram |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
chemistry.chemical_classification
Denticity Stereochemistry Myocardium General Engineering Cationic polymerization chemistry.chemical_element Heart Mixed ligand In Vitro Techniques Technetium Combinatorial chemistry In vitro Rats chemistry.chemical_compound Organophosphorus Compounds chemistry Yield (chemistry) Thiol Animals Humans Sulfhydryl Compounds Radionuclide Imaging Phosphine Sodium Pertechnetate Tc 99m |
| Zdroj: | International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes. 39:385-390 |
| ISSN: | 0883-2889 |
| DOI: | 10.1016/0883-2889(88)90067-6 |
| Popis: | TcO4− is reduced by a mixture of phosphine and thiol ligands to yield cationic complexes in which both ligands are coordinated. Polar and lipophilic properties of the products can easily be controlled by variation of either of the ligands. The yields are always high. Potential heart affinity of the compounds was screened by means of the isolated perfused rat heart. Some of the complexes show significant heart uptake and good retention in the myocardial tissue. |
| Databáze: | OpenAIRE |
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