Selecting human papillomavirus genotypes to optimize the performance of screening tests among South African women

Autor: Louise Kuhn, Zizipho Z. A. Mbulawa, David H. Persing, Ana I. Tergas, Lauren G. Johnson, Lynette Denny, Jennifer Moodley, Scott Campbell, Rosalind Boa, Thomas C. Wright, Wei-Yann Tsai, Anna-Lise Williamson, Rakiya Saidu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
0301 basic medicine
Cancer Research
medicine.medical_specialty
Genotype
HPV genotyping assays
Uterine Cervical Neoplasms
specificity
HIV Infections
Logistic regression
Cervical intraepithelial neoplasia
lcsh:RC254-282
Human Papillomavirus DNA Tests
03 medical and health sciences
South Africa
0302 clinical medicine
Predictive Value of Tests
Internal medicine
Cytology
Humans
Medicine
Radiology
Nuclear Medicine and imaging
Human papillomavirus
human papillomavirus
Papillomaviridae
Genotyping
Early Detection of Cancer
Original Research
Aged
Colposcopy
medicine.diagnostic_test
Coinfection
business.industry
Papillomavirus Infections
Reproducibility of Results
Middle Aged
Uterine Cervical Dysplasia
medicine.disease
sensitivity
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Adenocarcinoma
Female
Neoplasm Grading
business
Cancer Prevention
Zdroj: Cancer Medicine, Vol 9, Iss 18, Pp 6813-6824 (2020)
Cancer Medicine
ISSN: 2045-7634
Popis: Human papillomavirus (HPV) testing is highly sensitive compared to cytology, with the trade‐off of being less specific. We investigated whether select combinations of HPV genotypes, ascertained by Linear Array (LA) and Xpert HPV (GX), can optimize sensitivity/specificity trade‐offs to detect high‐grade cervical intraepithelial neoplasia (CIN2+). In a study in Cape Town, South Africa, 586 women living without and 535 living with HIV, aged 30‐65 years, were recruited. Each woman underwent a pelvic exam to collect cervical samples (tested by LA and GX for 14 high‐risk HPV genotypes) and underwent colposcopy with histological sampling to determine CIN2+. In multivariable logistic regression of LA results, only HPV genotypes 16, 18, 31, 33, 35, 52, 58 were significantly associated with CIN2+ (P
Human papillomavirus (HPV) testing is highly sensitive compared to cytology, with the trade‐off of being less specific. Among South African women, we have shown that restricting the definition of screen‐positive to women with HPV genotypes 16/18/45/31/33/35/52/58 substantially improves the specificity of screening while producing only minor reductions in sensitivity compared to inclusion of all 14 HPV genotypes conventionally included as high risk in HPV assays.
Databáze: OpenAIRE
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