A novel risk model to predict first-ever ischemic stroke in heart failure with reduced ejection fraction
| Autor: | Chenglong Xue, Lingfang Yu, Yinan Ji, Changzuan Zhou, Ruiyu Shi, Weizhen Hu, Xiaodong Zhou, Peiren Shan, Guojia Yu, Weijian Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Aging medicine.medical_specialty Heart Ventricles Risk Assessment Internal medicine Atrial Fibrillation medicine ischemic stroke Humans heart failure with reduced ejection fraction Heart Atria score model Aged Proportional Hazards Models Aged 80 and over Heart Failure Venous Thrombosis Framingham Risk Score Ejection fraction business.industry Proportional hazards model Anticoagulants Atrial fibrillation Stroke Volume Thrombosis Cell Biology Left ventricular thrombus Nomogram Middle Aged medicine.disease predictors Echocardiography Heart failure Cardiology Female business Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | Patients with heart failure are at increased risk for ischemic stroke. We aim to develop a more accurate stroke risk prediction tools identify high-risk patients with heart failure with reduced ejection fraction (HFrEF). Patient data were extracted retrospectively from the electronic medical database between January 2009 and February 2019. Univariate and multivariate Cox regression analysis were performed to identify independent predictors, which were utilized to construct a nomogram for predicting ischemic stroke. AUROC analysis was used to compare the prognostic value between the new risk score and CHADS2/CHA2DS2-VASc scores. In 6087 patients with HFrEF, the risk of first-ever ischemic stroke was 5.8% events/pts-years (n=468) during 8007.2 person-years follow-up. A nomogram constructed by integrating 6 variables, including age, atrial fibrillation (AF), deep vein thrombosis (DVT), d-dimer, anticoagulant use and spontaneous echocardiographic contrast (SEC)/left ventricular thrombus (LVT), exhibited a greater area under the curve of 0.727, 0.728 and 0.714 than that by CHADS2 score (0.515, 0.522 and 0.540), and by CHA2DS2-VASc score (0.547, 0.553 and 0.562) for predicting first-ever ischemic stroke at hospitalization, 30-day and 6-month follow-up (all p |
| Databáze: | OpenAIRE |
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