Membrane penetration and trapping of an active particle
| Autor: | Segun Goh, Andreas M. Menzel, Abdallah Daddi-Moussa-Ider, Arnold J. T. M. Mathijssen, Benno Liebchen, Christian Scholz, Hartmut Löwen, Christian Hoell, Francisca Guzmán-Lastra |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
General Physics and Astronomy Nanoparticle FOS: Physical sciences Condensed Matter - Soft Condensed Matter 010402 general chemistry Endocytosis 01 natural sciences Cell membrane 0103 physical sciences Organelle medicine Physical and Theoretical Chemistry Lipid bilayer 010304 chemical physics Cell Membrane Fluid Dynamics (physics.flu-dyn) Physics - Fluid Dynamics Penetration (firestop) 0104 chemical sciences medicine.anatomical_structure Membrane Biophysics Nanoparticles Magnetic nanoparticles Soft Condensed Matter (cond-mat.soft) |
| DOI: | 10.48550/arxiv.1901.07359 |
| Popis: | The interaction between nano- or micro-sized particles and cell membranes is of crucial importance in many biological and biomedical applications such as drug and gene delivery to cells and tissues. During their cellular uptake, the particles can pass through cell membranes via passive endocytosis or by active penetration to reach a target cellular compartment or organelle. In this manuscript, we develop a simple model to describe the interaction of a self-driven spherical particle (moving through an effective constant active force) with a minimal membrane system, allowing for both penetration and trapping. We numerically calculate the state diagram of this system, the membrane shape, and its dynamics. In this context, we show that the active particle may either get trapped near the membrane or penetrates through it, where the membrane can either be permanently destroyed or recover its initial shape by self-healing. Additionally, we systematically derive a continuum description allowing to accurately predict most of our results analytically. This analytical theory helps identifying the generic aspects of our model, suggesting that most of its ingredients should apply to a broad range of membranes, from simple model systems composed of magnetic microparticles to lipid bilayers. Our results might be useful to predict mechanical properties of synthetic minimal membranes. Comment: 16 pages, 6 figures. Revised manuscript resubmitted to J. Chem. Phys |
| Databáze: | OpenAIRE |
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