The impact of initial antibiotic treatment failure: Real-world insights in patients with complicated urinary tract infection
| Autor: | Kellie Ryan, Pascale Peeters, Sudeep Karve, Jesús Rodríguez-Baño, Elisa Baelen, Danielle Potter, Sonia Rojas-Farreras |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty Multivariate analysis medicine.drug_class Urinary system 030106 microbiology Antibiotics Disease Logistic regression 03 medical and health sciences 0302 clinical medicine Internal medicine Drug Resistance Multiple Bacterial Epidemiology medicine Escherichia coli Humans 030212 general & internal medicine Hospital Mortality Treatment Failure Intensive care medicine Aged Retrospective Studies Aged 80 and over Univariate analysis Cross Infection business.industry Medical record Middle Aged Anti-Bacterial Agents Hospitalization Klebsiella pneumoniae Infectious Diseases Pseudomonas aeruginosa Urinary Tract Infections Female Morbidity business |
| Zdroj: | The Journal of infection. 76(2) |
| ISSN: | 1532-2742 |
| Popis: | RECOMMEND (NCT02364284; D4280R00005) assessed treatment patterns and outcomes associated with initial antibiotic therapy (IAT; antibiotics received48 h post-initiation of antibiotic therapy) in healthcare-associated infections across five countries.Data from medical records of hospitalized patients aged ≥18 years with healthcare-associated complicated urinary tract infections (cUTI) are presented. Univariate and multivariate logistic regression analyses identified potential risk factors associated with IAT failure.Mean (SD) age was 68.7 (17.4) years (n = 408). In patients with microbiological documentation (357/408), Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa were most common (47.1%, 21.6% and 11.8%, respectively); 46.1% of patients had a multidrug resistant (MDR) pathogen isolated. Most patients received monotherapy IAT (72.5%). Mean IAT duration was 7.8 days. IAT failure, in-hospital mortality, and mortality 30-day post-discharge were 54.4%, 35.0% and 37.3%, respectively. IAT failure was associated with age, Deyo-Charlson comorbidity score, country, MDR status and ICU admission in the univariate analysis; and country and age in the multivariate analysis.This study provides real-world insights into the high rates of IAT failure and morbidity observed in patients with cUTI. Further study is imperative to understand the epidemiology of cUTI, support appropriate IAT selection and management, and reduce the burden of this disease. |
| Databáze: | OpenAIRE |
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