Antiphospholipid antibodies: Paradigm in transition
| Autor: | Alireza Minagar, Seyed Ali Mousavi, Wenche Jy, Amir H Maghzi, Yeon S. Ahn, Robert Zivadinov, Masoud Etemadifar, Roger E. Kelley, Lawrence L. Horstman, Carlos J. Bidot |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Multiple Sclerosis Neurology Immunology Thrombotic thrombocytopenic purpura Review lcsh:RC346-429 Cellular and Molecular Neuroscience immune system diseases Animals Humans Medicine Antigens neoplasms lcsh:Neurology. Diseases of the nervous system Purpura Thrombocytopenic Idiopathic biology business.industry General Neuroscience Multiple sclerosis Thrombosis medicine.disease Disease Models Animal Lupus Coagulation Inhibitor Antibodies Antiphospholipid biology.protein Antibody business |
| Zdroj: | Journal of Neuroinflammation Journal of Neuroinflammation, Vol 6, Iss 1, p 3 (2009) |
| ISSN: | 1742-2094 |
| DOI: | 10.1186/1742-2094-6-3 |
| Popis: | Objectives This is a critical review of anti-phospholipid antibodies (aPL). Most prior reviews focus on the aPL syndrome (APS), a thrombotic condition often marked by neurological disturbance. We bring to attention recent evidence that aPL may be equally relevant to non-thrombotic autoimmune conditions, notably, multiple sclerosis and ITP. Organization After a brief history, the recent proliferation of aPL target antigens is reviewed. The implication is that many more exist. Theories of aPL in thrombosis are then reviewed, concluding that all have merit but that aPL may have more diverse pathological consequences than now recognized. Next, conflicting results are explained by methodological differences. The lupus anticoagulant (LA) is then discussed. LA is the best predictor of thrombosis, but why this is true is not settled. Finally, aPL in non-thrombotic disorders is reviewed. Conclusion The current paradigm of aPL holds that they are important in thrombosis, but they may have much wider clinical significance, possibly of special interest in neurology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink