Fibronectin is up‐regulated in podocytes by mechanical stress

Autor:	Christian Scharf, Sindy Schröder, Christoph Daniel, Nicole Endlich, Henriette Lötzsch, Felix Kliewe, Karlhans Endlich, Maja T. Lindenmeyer, Sören Kaling, Maximilian Schindler, Henrik Rogge, Clemens D. Cohen, Kerstin Amann, Nadine Artelt
Rok vydání:	2019
Předmět:	0301 basic medicine Integrins Kidney Glomerulus Down-Regulation Biochemistry Diabetic nephropathy Extracellular matrix Mice 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Cell Adhesion Genetics medicine Animals Humans RNA Messenger skin and connective tissue diseases Molecular Biology Kidney Mechanical load biology Podocytes urogenital system Chemistry medicine.disease Biomechanical Phenomena Fibronectins Up-Regulation Cell biology Fibronectin 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation biology.protein Stress Mechanical sense organs Gene Deletion 030217 neurology & neurosurgery Biotechnology
Zdroj:	The FASEB Journal. 33:14450-14460
ISSN:	1530-6860 0892-6638
Popis:	Hypertension is one of the central causes of kidney damage. In the past it was shown that glomerular hypertension leads to morphologic changes of podocytes and effacement and is responsible for detachment of these postmitotic cells. Because we have shown that podocytes are mechanosensitive and respond to mechanical stress by reorganization of the actin cytoskeleton
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc22bf3c99456d8011bc7ebf6d4c94c https://doi.org/10.1096/fj.201900978rr Zobrazit plný text záznamu Plný text