Synthesis as an Expanding Resource in Human Milk Science
| Autor: | Lianyan L Xu, Steven D. Townsend |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Milk Human 010405 organic chemistry Chemistry Scale (chemistry) Oligosaccharides Translational research General Chemistry 01 natural sciences Biochemistry Data science Biological Science Disciplines Catalysis 0104 chemical sciences 03 medical and health sciences Synthetic biology Colloid and Surface Chemistry Resource (project management) Homogeneous Carbohydrate Conformation Humans Biological sciences 030304 developmental biology |
| Zdroj: | Journal of the American Chemical Society. 143:11277-11290 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | Few classes of natural products rival the structural audacity of oligosaccharides. Their complexity, however, has stood as an immense roadblock to translational research, as access to homogeneous material from nature is challenging. Thus, while carbohydrates are critical to the myriad functional and structural aspects of the biological sciences, their behavior is largely descriptive. This challenge presents an attractive opportunity for synthetic chemistry, particularly in the area of human milk science. First, there is an inordinate need for synthesizing homogeneous human milk oligosaccharides (HMOs). Superimposed on this goal is the mission of conducting syntheses at scale to enable animal studies. Herein, we present a personalized rumination of our involvement, and that of our colleagues, which has led to the synthesis and characterization of HMOs and mechanistic probes. Along the way, we highlight chemical, chemoenzymatic, and synthetic biology based approaches. We close with a discussion on emergent challenges and opportunities for synthesis, broadly defined, in human milk science. |
| Databáze: | OpenAIRE |
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